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TFEC

CANCER ATLAS

Gene description

 Transcription factor EC

Protein class

 Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB032260

GENE INFORMATION

Gene name

 TFEC (HGNC Symbol)

Synonyms

 bHLHe34, TCFEC, TFECL

Description

 Transcription factor EC (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 7

Cytoband

 q31.2

Chromosome location (bp)

 115935148 - 116159896

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105967 (version 83.38)

Entrez gene

 22797

UniProt

 O14948 (UniProt - Evidence at protein level)

neXtProt

 NX_O14948

Antibodypedia

 TFEC antibodies

PROTEIN BROWSER
TFEC-001
TFEC-002
TFEC-007
TFEC-008
TFEC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TFEC-001
ENSP00000265440
ENST00000265440
O14948 [Direct mapping]
Transcription factor EC
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Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0034605 [cellular response to heat]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 347 aa
38.8 kDa 		No 0
TFEC-002
ENSP00000377125
ENST00000393485
O14948 [Direct mapping]
Transcription factor EC
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 197 aa
22.7 kDa 		No 0
TFEC-007
ENSP00000318676
ENST00000320239
O14948 [Direct mapping]
Transcription factor EC
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 318 aa
35.5 kDa 		No 0
TFEC-008
ENSP00000417432
ENST00000484212
B7Z757 [Direct mapping]
Transcription factor EC; cDNA FLJ55256, highly similar to Homo sapiens transcription factor EC (TFEC), transcript variant 1, mRNA
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Predicted intracellular proteins
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
Show all
 316 aa
36.4 kDa 		No 0
TFEC-201
ENSP00000387650
ENST00000457268
O14948 [Direct mapping]
Transcription factor EC
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 280 aa
31.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.