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HIBADH

GENERAL INFORMATION

Gene name

 HIBADH

Gene description

 3-hydroxyisobutyrate dehydrogenase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA019522 , HPA021002
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HIBADH (HGNC Symbol)

Synonyms

 NS5ATP1

Description

 3-hydroxyisobutyrate dehydrogenase (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. [provided by RefSeq, Nov 2011]

Chromosome

 7

Cytoband

 p15.2

Chromosome location (bp)

 27525442 - 27662995

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106049 (version 83.38)

Entrez gene

 11112

UniProt

 P31937 (UniProt - Evidence at protein level)

neXtProt

 NX_P31937

Antibodypedia

 HIBADH antibodies

PROTEIN BROWSER
HIBADH-001
HIBADH-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIBADH-001
ENSP00000265395
ENST00000265395
P31937 [Direct mapping]
3-hydroxyisobutyrate dehydrogenase, mitochondrial
A0A024RA75 [Target identity:100%; Query identity:100%]
3-hydroxyisobutyrate dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006574 [valine catabolic process]
GO:0008442 [3-hydroxyisobutyrate dehydrogenase activity]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0016491 [oxidoreductase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
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 336 aa
35.3 kDa 		No 0
HIBADH-005
ENSP00000390205
ENST00000425715
H7BZL2 [Direct mapping]
3-hydroxyisobutyrate dehydrogenase, mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity]
GO:0008442 [3-hydroxyisobutyrate dehydrogenase activity]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
Show all
 206 aa
21.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.