Expression of SFRP4 in cancer - Summary

CANCER ATLAS

Gene description

Secreted frizzled-related protein 4

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA009712	HPA050585

GENE INFORMATION
Gene name	SFRP4 (HGNC Symbol)
Synonyms	FRP-4, frpHE
Description	Secreted frizzled-related protein 4 (HGNC Symbol)
Entrez gene summary	Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p14.1
Chromosome location (bp)	37905932 - 38025695
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106483 (version 83.38)
Entrez gene	6424
UniProt	Q6FHJ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6FHJ7
Antibodypedia	SFRP4 antibodies

PROTEIN BROWSER

SFRP4-001	SFRP4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFRP4-001 ENSP00000410715 ENST00000436072	Q6FHJ7 [Direct mapping] Secreted frizzled-related protein 4 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002092 [positive regulation of receptor internalization] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0017147 [Wnt-protein binding] GO:0030154 [cell differentiation] GO:0035567 [non-canonical Wnt signaling pathway] GO:0043065 [positive regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0055062 [phosphate ion homeostasis] GO:0060070 [canonical Wnt signaling pathway] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0098779 [mitophagy in response to mitochondrial depolarization] GO:1902174 [positive regulation of keratinocyte apoptotic process] GO:2000119 [negative regulation of sodium-dependent phosphate transport] Show all	346 aa 39.8 kDa	Yes	0
SFRP4-003 ENSP00000402262 ENST00000447200	C9JMJ2 [Direct mapping] Secreted frizzled-related protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0017147 [Wnt-protein binding] GO:0035567 [non-canonical Wnt signaling pathway] GO:0060070 [canonical Wnt signaling pathway] Show all	137 aa 15.8 kDa	No	0