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SFRP4

GENERAL INFORMATION

Gene name

 SFRP4

Gene description

 Secreted frizzled-related protein 4

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cervix, uterine, endometrium, fallopian tube)
GTEx:Group enriched (cervix, uterine, endometrium, vagina, ovary, fallopian tube, breast)
FANTOM5:Group enriched (cervix, uterine, retina, endometrium, ovary)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in stromal cells in both fallopian tube and endometrium as well as a subset of endometrial glandular cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA009712 , HPA050585
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, endometrium, fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, endometrium, vagina, ovary, fallopian tube, breast)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, retina, endometrium, ovary)

GENE INFORMATION

Gene name

 SFRP4 (HGNC Symbol)

Synonyms

 FRP-4, frpHE

Description

 Secreted frizzled-related protein 4 (HGNC Symbol)

Entrez gene summary

 Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p14.1

Chromosome location (bp)

 37905932 - 38025695

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106483 (version 83.38)

Entrez gene

 6424

UniProt

 Q6FHJ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6FHJ7

Antibodypedia

 SFRP4 antibodies

PROTEIN BROWSER
SFRP4-001
SFRP4-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SFRP4-001
ENSP00000410715
ENST00000436072
Q6FHJ7 [Direct mapping]
Secreted frizzled-related protein 4
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0008285 [negative regulation of cell proliferation]
GO:0009725 [response to hormone]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0017147 [Wnt-protein binding]
GO:0030154 [cell differentiation]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045606 [positive regulation of epidermal cell differentiation]
GO:0055062 [phosphate ion homeostasis]
GO:0060070 [canonical Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:2000119 [negative regulation of sodium-dependent phosphate transport]
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 346 aa
39.8 kDa 		Yes 0
SFRP4-003
ENSP00000402262
ENST00000447200
C9JMJ2 [Direct mapping]
Secreted frizzled-related protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0017147 [Wnt-protein binding]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0060070 [canonical Wnt signaling pathway]
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 137 aa
15.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.