Expression of MEOX2 in cancer - Summary

CANCER ATLAS

Gene description

Mesenchyme homeobox 2

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA053793

GENE INFORMATION
Gene name	MEOX2 (HGNC Symbol)
Synonyms	GAX, MOX2
Description	Mesenchyme homeobox 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p21.2
Chromosome location (bp)	15611212 - 15686812
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106511 (version 83.38)
Entrez gene	4223
UniProt	P50222 (UniProt - Evidence at protein level)
neXtProt	NX_P50222
Antibodypedia	MEOX2 antibodies

PROTEIN BROWSER

MEOX2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MEOX2-001 ENSP00000262041 ENST00000262041	P50222 [Direct mapping] Homeobox protein MOX-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001525 [angiogenesis] GO:0001757 [somite specification] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0007519 [skeletal muscle tissue development] GO:0008015 [blood circulation] GO:0016607 [nuclear speck] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060021 [palate development] GO:0060173 [limb development] GO:0070997 [neuron death] Show all	304 aa 33.6 kDa	No	0