Expression of POU6F2 in cancer - Summary

CANCER ATLAS

Gene description

POU class 6 homeobox 2

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008699

GENE INFORMATION
Gene name	POU6F2 (HGNC Symbol)
Synonyms	RPF-1
Description	POU class 6 homeobox 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Chromosome	7
Cytoband	p14.1
Chromosome location (bp)	38977998 - 39493095
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106536 (version 83.38)
Entrez gene	11281
UniProt	P78424 (UniProt - Evidence at protein level)
neXtProt	NX_P78424
Antibodypedia	POU6F2 antibodies

PROTEIN BROWSER

POU6F2-001	POU6F2-002	POU6F2-003	POU6F2-006	POU6F2-007	POU6F2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POU6F2-001 ENSP00000430514 ENST00000518318	P78424 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007402 [ganglion mother cell fate determination] GO:0007417 [central nervous system development] GO:0007601 [visual perception] Show all	655 aa 69.2 kDa	No	0
POU6F2-002 ENSP00000384004 ENST00000403058	P78424 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007402 [ganglion mother cell fate determination] GO:0007417 [central nervous system development] GO:0007601 [visual perception] Show all	691 aa 73.3 kDa	No	0
POU6F2-003 ENSP00000409684 ENST00000451021	C9JSC0 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	Predicted intracellular proteins Show all		145 aa 15 kDa	No	0
POU6F2-006 ENSP00000452911 ENST00000524147	H0YKR5 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	Predicted intracellular proteins Show all		412 aa 42.7 kDa	No	0
POU6F2-007 ENSP00000453020 ENST00000520104	H0YL15 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	Predicted intracellular proteins Show all		403 aa 41.6 kDa	No	0
POU6F2-011 ENSP00000452633 ENST00000559001	H0YK27 [Direct mapping] POU domain protein Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	636 aa 67.9 kDa	No	0