Tissue expression of POU6F2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	POU6F2
Gene description	POU class 6 homeobox 2
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, placenta)
GTEx:	Tissue enhanced (cerebral cortex)
FANTOM5:	Tissue enhanced (hippocampus, brain)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA008699
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus, brain)

GENE INFORMATION
Gene name	POU6F2 (HGNC Symbol)
Synonyms	RPF-1
Description	POU class 6 homeobox 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Chromosome	7
Cytoband	p14.1
Chromosome location (bp)	38977998 - 39493095
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106536 (version 83.38)
Entrez gene	11281
UniProt	P78424 (UniProt - Evidence at protein level)
neXtProt	NX_P78424
Antibodypedia	POU6F2 antibodies

PROTEIN BROWSER

POU6F2-001	POU6F2-002	POU6F2-003	POU6F2-006	POU6F2-007	POU6F2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POU6F2-001 ENSP00000430514 ENST00000518318	P78424 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007402 [ganglion mother cell fate determination] GO:0007417 [central nervous system development] GO:0007601 [visual perception] Show all	655 aa 69.2 kDa	No	0
POU6F2-002 ENSP00000384004 ENST00000403058	P78424 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007402 [ganglion mother cell fate determination] GO:0007417 [central nervous system development] GO:0007601 [visual perception] Show all	691 aa 73.3 kDa	No	0
POU6F2-003 ENSP00000409684 ENST00000451021	C9JSC0 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	Predicted intracellular proteins Show all		145 aa 15 kDa	No	0
POU6F2-006 ENSP00000452911 ENST00000524147	H0YKR5 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	Predicted intracellular proteins Show all		412 aa 42.7 kDa	No	0
POU6F2-007 ENSP00000453020 ENST00000520104	H0YL15 [Direct mapping] POU domain, class 6, transcription factor 2 Show all	Predicted intracellular proteins Show all		403 aa 41.6 kDa	No	0
POU6F2-011 ENSP00000452633 ENST00000559001	H0YK27 [Direct mapping] POU domain protein Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	636 aa 67.9 kDa	No	0