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RNA cell line category: Cell line enhanced (AF22, WM-115)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
GLI3 (HGNC Symbol)
Synonyms
ACLS, GCPS, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV
Description
GLI family zinc finger 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001656 [metanephros development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0002052 [positive regulation of neuroblast proliferation] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005929 [cilium] GO:0005930 [axoneme] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007224 [smoothened signaling pathway] GO:0007389 [pattern specification process] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0007442 [hindgut morphogenesis] GO:0007507 [heart development] GO:0008013 [beta-catenin binding] GO:0008285 [negative regulation of cell proliferation] GO:0009952 [anterior/posterior pattern specification] GO:0009953 [dorsal/ventral pattern formation] GO:0009954 [proximal/distal pattern formation] GO:0010468 [regulation of gene expression] GO:0016485 [protein processing] GO:0016592 [mediator complex] GO:0016607 [nuclear speck] GO:0017053 [transcriptional repressor complex] GO:0021513 [spinal cord dorsal/ventral patterning] GO:0021522 [spinal cord motor neuron differentiation] GO:0021537 [telencephalon development] GO:0021543 [pallium development] GO:0021544 [subpallium development] GO:0021631 [optic nerve morphogenesis] GO:0021766 [hippocampus development] GO:0021775 [smoothened signaling pathway involved in ventral spinal cord interneuron specification] GO:0021776 [smoothened signaling pathway involved in spinal cord motor neuron cell fate specification] GO:0021798 [forebrain dorsal/ventral pattern formation] GO:0021801 [cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0021861 [forebrain radial glial cell differentiation] GO:0021915 [neural tube development] GO:0022018 [lateral ganglionic eminence cell proliferation] GO:0030318 [melanocyte differentiation] GO:0030324 [lung development] GO:0030326 [embryonic limb morphogenesis] GO:0030879 [mammary gland development] GO:0030900 [forebrain development] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0033077 [T cell differentiation in thymus] GO:0035035 [histone acetyltransferase binding] GO:0035108 [limb morphogenesis] GO:0035295 [tube development] GO:0042060 [wound healing] GO:0042127 [regulation of cell proliferation] GO:0042307 [positive regulation of protein import into nucleus] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042733 [embryonic digit morphogenesis] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043010 [camera-type eye development] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0043585 [nose morphogenesis] GO:0043586 [tongue development] GO:0043627 [response to estrogen] GO:0045060 [negative thymic T cell selection] GO:0045595 [regulation of cell differentiation] GO:0045596 [negative regulation of cell differentiation] GO:0045665 [negative regulation of neuron differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046638 [positive regulation of alpha-beta T cell differentiation] GO:0046639 [negative regulation of alpha-beta T cell differentiation] GO:0046872 [metal ion binding] GO:0048557 [embryonic digestive tract morphogenesis] GO:0048566 [embryonic digestive tract development] GO:0048589 [developmental growth] GO:0048593 [camera-type eye morphogenesis] GO:0048598 [embryonic morphogenesis] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0048663 [neuron fate commitment] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048709 [oligodendrocyte differentiation] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048839 [inner ear development] GO:0048856 [anatomical structure development] GO:0060021 [palate development] GO:0060173 [limb development] GO:0060364 [frontal suture morphogenesis] GO:0060366 [lambdoid suture morphogenesis] GO:0060367 [sagittal suture morphogenesis] GO:0060594 [mammary gland specification] GO:0060831 [smoothened signaling pathway involved in dorsal/ventral neural tube patterning] GO:0060840 [artery development] GO:0060873 [anterior semicircular canal development] GO:0060875 [lateral semicircular canal development] GO:0061005 [cell differentiation involved in kidney development] GO:0070242 [thymocyte apoptotic process] GO:0072372 [primary cilium] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097542 [ciliary tip] GO:0097546 [ciliary base]