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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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GLI3
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

GLI family zinc finger 3

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA005534

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells displayed weak to moderate nuclear staining, often only in a few cells. A few cervical cancers, breast cancers and melanomas were strongly stained.

GENE INFORMATION

Gene name

GLI3 (HGNC Symbol)

Synonyms

ACLS, GCPS, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV

Description

GLI family zinc finger 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p14.1

Chromosome location (bp)

41960950 - 42237870

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106571 (version 83.38)

Entrez gene

2737

UniProt

P10071 (UniProt - Evidence at protein level)

neXtProt

NX_P10071

Antibodypedia

GLI3 antibodies

PROTEIN BROWSER

GLI3-001
GLI3-004
GLI3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLI3-001
ENSP00000379258
ENST00000395925
P10071 [Direct mapping]
Transcriptional activator GLI3 Transcriptional repressor GLI3R
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007224 [smoothened signaling pathway]
GO:0007389 [pattern specification process]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0007442 [hindgut morphogenesis]
GO:0007507 [heart development]
GO:0008013 [beta-catenin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009952 [anterior/posterior pattern specification]
GO:0009953 [dorsal/ventral pattern formation]
GO:0009954 [proximal/distal pattern formation]
GO:0010468 [regulation of gene expression]
GO:0016485 [protein processing]
GO:0016592 [mediator complex]
GO:0016607 [nuclear speck]
GO:0017053 [transcriptional repressor complex]
GO:0021513 [spinal cord dorsal/ventral patterning]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0021537 [telencephalon development]
GO:0021543 [pallium development]
GO:0021544 [subpallium development]
GO:0021631 [optic nerve morphogenesis]
GO:0021766 [hippocampus development]
GO:0021775 [smoothened signaling pathway involved in ventral spinal cord interneuron specification]
GO:0021776 [smoothened signaling pathway involved in spinal cord motor neuron cell fate specification]
GO:0021798 [forebrain dorsal/ventral pattern formation]
GO:0021801 [cerebral cortex radial glia guided migration]
GO:0021819 [layer formation in cerebral cortex]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021915 [neural tube development]
GO:0022018 [lateral ganglionic eminence cell proliferation]
GO:0030318 [melanocyte differentiation]
GO:0030324 [lung development]
GO:0030326 [embryonic limb morphogenesis]
GO:0030879 [mammary gland development]
GO:0030900 [forebrain development]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0033077 [T cell differentiation in thymus]
GO:0035035 [histone acetyltransferase binding]
GO:0035108 [limb morphogenesis]
GO:0035295 [tube development]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042733 [embryonic digit morphogenesis]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043585 [nose morphogenesis]
GO:0043586 [tongue development]
GO:0043627 [response to estrogen]
GO:0045060 [negative thymic T cell selection]
GO:0045595 [regulation of cell differentiation]
GO:0045596 [negative regulation of cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046638 [positive regulation of alpha-beta T cell differentiation]
GO:0046639 [negative regulation of alpha-beta T cell differentiation]
GO:0046872 [metal ion binding]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048566 [embryonic digestive tract development]
GO:0048589 [developmental growth]
GO:0048593 [camera-type eye morphogenesis]
GO:0048598 [embryonic morphogenesis]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048663 [neuron fate commitment]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048709 [oligodendrocyte differentiation]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048839 [inner ear development]
GO:0048856 [anatomical structure development]
GO:0060021 [palate development]
GO:0060173 [limb development]
GO:0060364 [frontal suture morphogenesis]
GO:0060366 [lambdoid suture morphogenesis]
GO:0060367 [sagittal suture morphogenesis]
GO:0060594 [mammary gland specification]
GO:0060831 [smoothened signaling pathway involved in dorsal/ventral neural tube patterning]
GO:0060840 [artery development]
GO:0060873 [anterior semicircular canal development]
GO:0060875 [lateral semicircular canal development]
GO:0061005 [cell differentiation involved in kidney development]
GO:0070242 [thymocyte apoptotic process]
GO:0072372 [primary cilium]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
Show all
1580 aa
169.9 kDa
No 0
GLI3-004
ENSP00000407963
ENST00000437480
F8WEV4 [Direct mapping]
Transcriptional activator GLI3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
96 aa
10.3 kDa
No 0
GLI3-005
ENSP00000406135
ENST00000448703
C9J9N4 [Direct mapping]
Transcriptional activator GLI3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
180 aa
20.1 kDa
No 0

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