Expression of SLC1A1 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA020086	CAB015466

GENE INFORMATION
Gene name	SLC1A1 (HGNC Symbol)
Synonyms	EAAC1, EAAT3
Description	Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
Chromosome	9
Cytoband	p24.2
Chromosome location (bp)	4490444 - 4587469
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106688 (version 83.38)
Entrez gene	6505
UniProt	P43005 (UniProt - Evidence at protein level)
neXtProt	NX_P43005
Antibodypedia	SLC1A1 antibodies

PROTEIN BROWSER

SLC1A1-001	SLC1A1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC1A1-001 ENSP00000262352 ENST00000262352	P43005 [Direct mapping] Excitatory amino acid transporter 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005313 [L-glutamate transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006835 [dicarboxylic acid transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0010460 [positive regulation of heart rate] GO:0014047 [glutamate secretion] GO:0015501 [glutamate:sodium symporter activity] GO:0015813 [L-glutamate transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0016595 [glutamate binding] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0033229 [cysteine transmembrane transporter activity] GO:0042883 [cysteine transport] GO:0051260 [protein homooligomerization] GO:0051938 [L-glutamate import] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070779 [D-aspartate import] GO:0089711 [L-glutamate transmembrane transport] GO:1903712 [cysteine transmembrane transport] Show all	524 aa 57.1 kDa	No	>9
SLC1A1-002 ENSP00000414620 ENST00000422398	H0Y7R2 [Direct mapping] Amino acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] Show all	242 aa 26.6 kDa	No	3