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SLC1A1

GENERAL INFORMATION

Gene name

 SLC1A1

Gene description

 Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (small intestine)
GTEx:Tissue enhanced (small intestine)
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression a variable levels in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA020086 , CAB015466
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

 SLC1A1 (HGNC Symbol)

Synonyms

 EAAC1, EAAT3

Description

 Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

Chromosome

 9

Cytoband

 p24.2

Chromosome location (bp)

 4490444 - 4587469

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106688 (version 83.38)

Entrez gene

 6505

UniProt

 P43005 (UniProt - Evidence at protein level)

neXtProt

 NX_P43005

Antibodypedia

 SLC1A1 antibodies

PROTEIN BROWSER
SLC1A1-001
SLC1A1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC1A1-001
ENSP00000262352
ENST00000262352
P43005 [Direct mapping]
Excitatory amino acid transporter 3
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0010460 [positive regulation of heart rate]
GO:0014047 [glutamate secretion]
GO:0015501 [glutamate:sodium symporter activity]
GO:0015813 [L-glutamate transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0016595 [glutamate binding]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0033229 [cysteine transmembrane transporter activity]
GO:0042883 [cysteine transport]
GO:0051260 [protein homooligomerization]
GO:0051938 [L-glutamate import]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070779 [D-aspartate import]
GO:0089711 [L-glutamate transmembrane transport]
GO:1903712 [cysteine transmembrane transport]
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 524 aa
57.1 kDa 		No >9
SLC1A1-002
ENSP00000414620
ENST00000422398
H0Y7R2 [Direct mapping]
Amino acid transporter
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006835 [dicarboxylic acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0055085 [transmembrane transport]
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 242 aa
26.6 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.