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Most cancer tissues showed weak to moderate cytoplasmic positivity. Several hepatocellular carcinomas were strongly stained. Additional membranous staining was observed in a few cases of colorectal cancers. Several breast cancers and a few lung adenocarcinomas displayed additional nuclear positivity.
GENE INFORMATION
Gene name
CDC37L1 (HGNC Symbol)
Synonyms
CDC37B, FLJ20639, HARC
Description
Cell division cycle 37-like 1 (HGNC Symbol)
Entrez gene summary
CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]