Cell atlas - ELAVL2 - The Human Protein Atlas

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ELAVL2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ELAVL2
Gene description	ELAV like neuron-specific RNA binding protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (SCLC-21H, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA063001
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063001	A-431	Nucleoplasm
	HPA063001	SH-SY5Y	Nucleoplasm
	HPA063001	U-2 OS	Nucleoplasm
	HPA063001	U-2 OS	Cytosol

GENE INFORMATION
Gene name	ELAVL2 (HGNC Symbol)
Synonyms	HEL-N1, HuB
Description	ELAV like neuron-specific RNA binding protein 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Chromosome	9
Cytoband	p21.3
Chromosome location (bp)	23690104 - 23826337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107105 (version 83.38)
Entrez gene	1993
UniProt	Q12926 (UniProt - Evidence at protein level)
neXtProt	NX_Q12926
Antibodypedia	ELAVL2 antibodies

PROTEIN BROWSER

ELAVL2-001	ELAVL2-002	ELAVL2-003	ELAVL2-004	ELAVL2-005	ELAVL2-201	ELAVL2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ELAVL2-001 ENSP00000369460 ENST00000380117	Q12926 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	359 aa 39.5 kDa	No	0
ELAVL2-002 ENSP00000223951 ENST00000223951	Q12926 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	346 aa 38 kDa	No	0
ELAVL2-003 ENSP00000412602 ENST00000440102	B1AM48 [Direct mapping] ELAV-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	189 aa 20.7 kDa	No	0
ELAVL2-004 ENSP00000369453 ENST00000380110	A0A0A0MRX1 [Direct mapping] ELAV-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	389 aa 42.6 kDa	No	0
ELAVL2-005 ENSP00000391757 ENST00000423281	C9JB16 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	90 aa 10.1 kDa	No	0
ELAVL2-201 ENSP00000380479 ENST00000397312	Q12926 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	359 aa 39.5 kDa	No	0
ELAVL2-202 ENSP00000440998 ENST00000544538	Q12926 [Direct mapping] ELAV-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	359 aa 39.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.