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PDLIM1

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GENERAL INFORMATION

Gene name

 PDLIM1

Gene description

 PDZ and LIM domain 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the actin filaments. In addition localized to the plasma membrane & cell junctions.

RNA cell category

 Cell line enhanced (HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Actin filaments (supported)

Additional location

 In addition localized to the Plasma membrane (approved), Cell Junctions (approved)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
CAB072838 , CAB072840
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the actin filaments. In addition localized to the plasma membrane & cell junctions.

Main location

 Actin filaments (supported)

Additional location

 Plasma membrane (approved), Cell Junctions (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB072838 HeLa Actin filaments
CAB072838 MCF7 No staining    
CAB072840 HeLa Plasma membrane
Actin filaments
CAB072840 MCF7 Cell Junctions
CAB072840 U-2 OS Plasma membrane

GENE INFORMATION

Gene name

 PDLIM1 (HGNC Symbol)

Synonyms

 CLIM1, CLP-36, CLP36, hCLIM1

Description

 PDZ and LIM domain 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012]

Chromosome

 10

Cytoband

 q23.33

Chromosome location (bp)

 95237572 - 95291024

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107438 (version 83.38)

Entrez gene

 9124

UniProt

 O00151 (UniProt - Evidence at protein level)

neXtProt

 NX_O00151

Antibodypedia

 PDLIM1 antibodies

PROTEIN BROWSER
PDLIM1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDLIM1-001
ENSP00000360305
ENST00000329399
O00151 [Direct mapping]
PDZ and LIM domain protein 1
V9HW92 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 112; PDZ and LIM domain 1 (Elfin), isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006979 [response to oxidative stress]
GO:0008270 [zinc ion binding]
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 329 aa
36.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.