Expression of ACTA2 in cancer - Summary

CANCER ATLAS

Gene description

Actin, alpha 2, smooth muscle, aorta

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA041264	HPA041271	CAB000002	CAB013531

GENE INFORMATION
Gene name	ACTA2 (HGNC Symbol)
Synonyms	ACTSA
Description	Actin, alpha 2, smooth muscle, aorta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Chromosome	10
Cytoband	q23.31
Chromosome location (bp)	88935074 - 88991390
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107796 (version 83.38)
Entrez gene	59
UniProt	P62736 (UniProt - Evidence at protein level)
neXtProt	NX_P62736
Antibodypedia	ACTA2 antibodies

PROTEIN BROWSER

ACTA2-001	ACTA2-002	ACTA2-003	ACTA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACTA2-001 ENSP00000224784 ENST00000224784	P62736 [Direct mapping] Actin, aortic smooth muscle D2JYH4 [Target identity:100%; Query identity:100%] Actin, alpha 2, smooth muscle, aorta; Actin, alpha 2, smooth muscle, aorta, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0009615 [response to virus] GO:0010628 [positive regulation of gene expression] GO:0019901 [protein kinase binding] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0043234 [protein complex] GO:0044297 [cell body] GO:0070062 [extracellular exosome] GO:0072144 [glomerular mesangial cell development] GO:0090131 [mesenchyme migration] Show all	377 aa 42 kDa	No	0
ACTA2-002 ENSP00000396730 ENST00000415557	F6QUT6 [Direct mapping] Actin, aortic smooth muscle Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		151 aa 16.8 kDa	No	0
ACTA2-003 ENSP00000398239 ENST00000458159	F6UVQ4 [Direct mapping] Actin, aortic smooth muscle Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		151 aa 16.8 kDa	No	0
ACTA2-201 ENSP00000402373 ENST00000458208	P62736 [Direct mapping] Actin, aortic smooth muscle D2JYH4 [Target identity:100%; Query identity:100%] Actin, alpha 2, smooth muscle, aorta; Actin, alpha 2, smooth muscle, aorta, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006936 [muscle contraction] GO:0008217 [regulation of blood pressure] GO:0009615 [response to virus] GO:0010628 [positive regulation of gene expression] GO:0014829 [vascular smooth muscle contraction] GO:0019901 [protein kinase binding] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030485 [smooth muscle contractile fiber] GO:0043234 [protein complex] GO:0044297 [cell body] GO:0070062 [extracellular exosome] GO:0072144 [glomerular mesangial cell development] GO:0090131 [mesenchyme migration] Show all	377 aa 42 kDa	No	0