Expression of LARP4B in cancer - Summary

CANCER ATLAS

Gene description

La ribonucleoprotein domain family, member 4B

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036566

GENE INFORMATION
Gene name	LARP4B (HGNC Symbol)
Synonyms	KIAA0217, LARP5
Description	La ribonucleoprotein domain family, member 4B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]
Chromosome	10
Cytoband	p15.3
Chromosome location (bp)	806914 - 931705
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107929 (version 83.38)
Entrez gene	23185
UniProt	Q92615 (UniProt - Evidence at protein level)
neXtProt	NX_Q92615
Antibodypedia	LARP4B antibodies

PROTEIN BROWSER

LARP4B-002	LARP4B-003	LARP4B-004	LARP4B-007	LARP4B-008	LARP4B-011	LARP4B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LARP4B-002 ENSP00000326128 ENST00000316157	Q92615 [Direct mapping] La-related protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0010494 [cytoplasmic stress granule] GO:0016020 [membrane] GO:0042788 [polysomal ribosome] GO:0044822 [poly(A) RNA binding] GO:0045727 [positive regulation of translation] Show all	738 aa 80.6 kDa	No	0
LARP4B-003 ENSP00000385229 ENST00000406525	B5MCU2 [Direct mapping] La-related protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 13.5 kDa	No	0
LARP4B-004 ENSP00000390556 ENST00000412411	X6RCG6 [Direct mapping] La-related protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		57 aa 6.1 kDa	No	0
LARP4B-007 ENSP00000394545 ENST00000448368	H0Y4V9 [Direct mapping] La-related protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		339 aa 36.5 kDa	No	0
LARP4B-008 ENSP00000403018 ENST00000440895	H0Y641 [Direct mapping] La-related protein 4B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		190 aa 20.3 kDa	No	1
LARP4B-011 ENSP00000483973 ENST00000614908	A0A087X183 [Direct mapping] La-related protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 16.5 kDa	No	0
LARP4B-201 ENSP00000482767 ENST00000612396	Q92615 [Direct mapping] La-related protein 4B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0010494 [cytoplasmic stress granule] GO:0016020 [membrane] GO:0042788 [polysomal ribosome] GO:0044822 [poly(A) RNA binding] GO:0045727 [positive regulation of translation] Show all	738 aa 80.6 kDa	No	0