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CUL2

CANCER ATLAS

Gene description

 Cullin 2

Protein class

 Cancer-related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024578
CAB002677

GENE INFORMATION

Gene name

 CUL2

Synonyms

Description

 Cullin 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 p11.21

Chromosome location (bp)

 35008551 - 35090642

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108094 (version 83.38)

Entrez gene

 8453

UniProt

 Q13617 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13617

Antibodypedia

 CUL2 antibodies

PROTEIN BROWSER
CUL2-001
CUL2-002
CUL2-004
CUL2-005
CUL2-006
CUL2-201
CUL2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CUL2-001
ENSP00000363883
ENST00000374751
Q13617 [Direct mapping]
Cullin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031462 [Cul2-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071456 [cellular response to hypoxia]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 745 aa
87 kDa 		No 0
CUL2-002
ENSP00000363880
ENST00000374748
Q13617 [Direct mapping]
Cullin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031462 [Cul2-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071456 [cellular response to hypoxia]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 745 aa
87 kDa 		No 0
CUL2-004
ENSP00000414095
ENST00000421317
Q13617 [Direct mapping]
Cullin-2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0030163 [protein catabolic process]
GO:0030891 [VCB complex]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031462 [Cul2-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032403 [protein complex binding]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071456 [cellular response to hypoxia]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 764 aa
89.5 kDa 		No 0
CUL2-005
ENSP00000363878
ENST00000374746
Q5T2B5 [Direct mapping]
Cullin-2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
Show all
 706 aa
82.4 kDa 		No 0
CUL2-006
ENSP00000363881
ENST00000374749
Q13617 [Direct mapping]
Cullin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031462 [Cul2-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071456 [cellular response to hypoxia]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 745 aa
87 kDa 		No 0
CUL2-201
ENSP00000444856
ENST00000537177
A0A0A0MTN0 [Direct mapping]
Cullin-2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
Show all
 758 aa
88.5 kDa 		No 0
CUL2-202
ENSP00000485986
ENST00000626172
Q5T2B5 [Direct mapping]
Cullin-2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
Show all
 706 aa
82.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.