Cell atlas - CUL2 - The Human Protein Atlas

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CUL2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CUL2
Gene description	Cullin 2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB002677 , HPA024578
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024578	PC-3	Nucleoplasm
	CAB002677	A-431	Nucleoplasm
	CAB002677	U-2 OS	Nucleoplasm
	CAB002677	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	CUL2
Synonyms
Description	Cullin 2 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	p11.21
Chromosome location (bp)	35008551 - 35090642
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108094 (version 83.38)
Entrez gene	8453
UniProt	Q13617 (UniProt - Evidence at protein level)
neXtProt	NX_Q13617
Antibodypedia	CUL2 antibodies

PROTEIN BROWSER

CUL2-001	CUL2-002	CUL2-004	CUL2-005	CUL2-006	CUL2-201	CUL2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CUL2-001 ENSP00000363883 ENST00000374751	Q13617 [Direct mapping] Cullin-2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0016032 [viral process] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061630 [ubiquitin protein ligase activity] GO:0071456 [cellular response to hypoxia] GO:0097193 [intrinsic apoptotic signaling pathway] Show all	745 aa 87 kDa	No	0
CUL2-002 ENSP00000363880 ENST00000374748	Q13617 [Direct mapping] Cullin-2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0016032 [viral process] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061630 [ubiquitin protein ligase activity] GO:0071456 [cellular response to hypoxia] GO:0097193 [intrinsic apoptotic signaling pathway] Show all	745 aa 87 kDa	No	0
CUL2-004 ENSP00000414095 ENST00000421317	Q13617 [Direct mapping] Cullin-2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0016032 [viral process] GO:0030163 [protein catabolic process] GO:0030891 [VCB complex] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0032403 [protein complex binding] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061630 [ubiquitin protein ligase activity] GO:0071456 [cellular response to hypoxia] GO:0097193 [intrinsic apoptotic signaling pathway] Show all	764 aa 89.5 kDa	No	0
CUL2-005 ENSP00000363878 ENST00000374746	Q5T2B5 [Direct mapping] Cullin-2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] Show all	706 aa 82.4 kDa	No	0
CUL2-006 ENSP00000363881 ENST00000374749	Q13617 [Direct mapping] Cullin-2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0016032 [viral process] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061630 [ubiquitin protein ligase activity] GO:0071456 [cellular response to hypoxia] GO:0097193 [intrinsic apoptotic signaling pathway] Show all	745 aa 87 kDa	No	0
CUL2-201 ENSP00000444856 ENST00000537177	A0A0A0MTN0 [Direct mapping] Cullin-2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] Show all	758 aa 88.5 kDa	No	0
CUL2-202 ENSP00000485986 ENST00000626172	Q5T2B5 [Direct mapping] Cullin-2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] Show all	706 aa 82.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.