Cell atlas - KRT23 - The Human Protein Atlas

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KRT23

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Intermediate filaments

Human cell
	Cytosol
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	KRT23
Gene description	Keratin 23, type I
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the intermediate filaments. In addition localized to the cytosol.
RNA cell category	Group enriched (T-47d, Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB017091
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (T-47d, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the intermediate filaments. In addition localized to the cytosol.

Main location

Intermediate filaments (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB017091	A-431	Intermediate filaments
	CAB017091	A-431	Cytosol

GENE INFORMATION
Gene name	KRT23 (HGNC Symbol)
Synonyms	CK23, DKFZP434G032, HAIK1, K23, MGC26158
Description	Keratin 23, type I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	40922696 - 40937634
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108244 (version 83.38)
Entrez gene	25984
UniProt	Q9C075 (UniProt - Evidence at protein level)
neXtProt	NX_Q9C075
Antibodypedia	KRT23 antibodies

PROTEIN BROWSER

KRT23-001	KRT23-004	KRT23-005	KRT23-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT23-001 ENSP00000209718 ENST00000209718	Q9C075 [Direct mapping] Keratin, type I cytoskeletal 23 A0A024R1X9 [Target identity:100%; Query identity:100%] Keratin 23 (Histone deacetylase inducible), isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	422 aa 48.1 kDa	No	0
KRT23-004 ENSP00000467393 ENST00000485751	K7EPI0 [Direct mapping] Keratin, type I cytoskeletal 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.3 kDa	No	0
KRT23-005 ENSP00000414056 ENST00000436344	Q9C075 [Direct mapping] Keratin, type I cytoskeletal 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	285 aa 33.3 kDa	No	0
KRT23-010 ENSP00000464051 ENST00000584517	J3QR55 [Direct mapping] Keratin, type I cytoskeletal 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	149 aa 17.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.