Tissue expression of KRT23 - Summary - The Human Protein Atlas

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KRT23

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	KRT23
Gene description	Keratin 23, type I
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skin, placenta)
GTEx:	Tissue enhanced (skin, salivary gland)
FANTOM5:	Group enriched (placenta, salivary gland)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression predominantly in epithelial tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA012050 , HPA016959 , CAB017091
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin, salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (placenta, salivary gland)

GENE INFORMATION
Gene name	KRT23 (HGNC Symbol)
Synonyms	CK23, DKFZP434G032, HAIK1, K23, MGC26158
Description	Keratin 23, type I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	40922696 - 40937634
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108244 (version 83.38)
Entrez gene	25984
UniProt	Q9C075 (UniProt - Evidence at protein level)
neXtProt	NX_Q9C075
Antibodypedia	KRT23 antibodies

PROTEIN BROWSER

KRT23-001	KRT23-004	KRT23-005	KRT23-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT23-001 ENSP00000209718 ENST00000209718	Q9C075 [Direct mapping] Keratin, type I cytoskeletal 23 A0A024R1X9 [Target identity:100%; Query identity:100%] Keratin 23 (Histone deacetylase inducible), isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	422 aa 48.1 kDa	No	0
KRT23-004 ENSP00000467393 ENST00000485751	K7EPI0 [Direct mapping] Keratin, type I cytoskeletal 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.3 kDa	No	0
KRT23-005 ENSP00000414056 ENST00000436344	Q9C075 [Direct mapping] Keratin, type I cytoskeletal 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	285 aa 33.3 kDa	No	0
KRT23-010 ENSP00000464051 ENST00000584517	J3QR55 [Direct mapping] Keratin, type I cytoskeletal 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	149 aa 17.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.