Expression of CASC3 in cancer - Summary

CANCER ATLAS

Gene description

Cancer susceptibility candidate 3

Protein class

Cancer-related genes, Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024592

GENE INFORMATION
Gene name	CASC3 (HGNC Symbol)
Synonyms	BTZ, MLN51
Description	Cancer susceptibility candidate 3 (HGNC Symbol)
Entrez gene summary	The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.1
Chromosome location (bp)	40140318 - 40172183
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108349 (version 83.38)
Entrez gene	22794
UniProt	O15234 (UniProt - Evidence at protein level)
neXtProt	NX_O15234
Antibodypedia	CASC3 antibodies

PROTEIN BROWSER

CASC3-001	CASC3-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASC3-001 ENSP00000264645 ENST00000264645	O15234 [Direct mapping] Protein CASC3 Show all	Transporters Primary Active Transporters Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006397 [mRNA processing] GO:0006417 [regulation of translation] GO:0008150 [biological_process] GO:0008298 [intracellular mRNA localization] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016070 [RNA metabolic process] GO:0016607 [nuclear speck] GO:0019899 [enzyme binding] GO:0030529 [ribonucleoprotein complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035145 [exon-exon junction complex] GO:0042802 [identical protein binding] GO:0044822 [poly(A) RNA binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051028 [mRNA transport] Show all	703 aa 76.3 kDa	No	0
CASC3-007 ENSP00000467654 ENST00000584997	K7EQ38 [Direct mapping] Protein CASC3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.2 kDa	No	0