Cell atlas - CASC3 - The Human Protein Atlas

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CASC3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane

Human cell
	Nuclear membrane

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GENERAL INFORMATION
Gene name	CASC3
Gene description	Cancer susceptibility candidate 3
Protein class	Cancer-related genes Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Mouse	Localized to the Nuclear membrane, Microtubule organizing center in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA050262
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane.

Main location

Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050262	A-431	Nuclear membrane
	HPA050262	HEK 293	Nuclear membrane
	HPA050262	U-2 OS	Nuclear membrane

MOUSE CELLS

Main location

Nuclear membrane, Microtubule organizing center

Mouse gene

ENSMUSG00000078676 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA050262	NIH 3T3	Nuclear membrane
	HPA050262	NIH 3T3	Microtubule organizing center

GENE INFORMATION
Gene name	CASC3 (HGNC Symbol)
Synonyms	BTZ, MLN51
Description	Cancer susceptibility candidate 3 (HGNC Symbol)
Entrez gene summary	The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.1
Chromosome location (bp)	40140318 - 40172183
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108349 (version 83.38)
Entrez gene	22794
UniProt	O15234 (UniProt - Evidence at protein level)
neXtProt	NX_O15234
Antibodypedia	CASC3 antibodies

PROTEIN BROWSER

CASC3-001	CASC3-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASC3-001 ENSP00000264645 ENST00000264645	O15234 [Direct mapping] Protein CASC3 Show all	Transporters Primary Active Transporters Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006397 [mRNA processing] GO:0006417 [regulation of translation] GO:0008150 [biological_process] GO:0008298 [intracellular mRNA localization] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016070 [RNA metabolic process] GO:0016607 [nuclear speck] GO:0019899 [enzyme binding] GO:0030529 [ribonucleoprotein complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035145 [exon-exon junction complex] GO:0042802 [identical protein binding] GO:0044822 [poly(A) RNA binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051028 [mRNA transport] Show all	703 aa 76.3 kDa	No	0
CASC3-007 ENSP00000467654 ENST00000584997	K7EQ38 [Direct mapping] Protein CASC3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.