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KPNB1

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GENERAL INFORMATION

Gene name

 KPNB1

Gene description

 Karyopherin (importin) beta 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear membrane, cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Nuclear membrane (supported), Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA029878 , HPA050302
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ASSAYS
RNA expression
Human cells
GFP
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear membrane, cytosol & nucleoplasm.

Main location

 Nucleoplasm (supported), Nuclear membrane (supported), Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA029878 A-431 Nucleoplasm
Nuclear membrane
Cytosol
HPA029878 U-2 OS Nuclear membrane
Cytosol
HPA029878 U-251 MG Cytosol
HPA050302 A-431 Nucleoplasm
Nuclear membrane Intensity
Cytosol
HPA050302 CACO-2 Nuclear membrane
HPA050302 U-2 OS No staining    

GFP

Antibody

 HPA029878

Validation

N-terminal tag
BAC cell line: 5737
Validated: Antibody staining overlaps with GFP tagged protein but show additional locations

Antibody

 HPA050302

Validation

N-terminal tag
BAC cell line: 5737
Validated: Antibody staining overlaps with GFP tagged protein but show additional locations

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA029878 HeLa 5737 N-terminal Nucleoplasm, Nuclear membrane, Cytosol Nucleoplasm, Cytosol
HPA029878 HeLa Normal - Nuclear membrane, Cytosol -
HPA050302 HeLa 5737 N-terminal Nucleoplasm, Nuclear membrane, Cytosol Nucleoplasm, Cytosol
HPA050302 HeLa Normal - Nuclear membrane, Cytosol -

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000001440 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA050302 NIH 3T3 No staining

GENE INFORMATION

Gene name

 KPNB1 (HGNC Symbol)

Synonyms

 IMB1, Impnb, IPO1, IPOB, MGC2155, MGC2156, MGC2157, NTF97

Description

 Karyopherin (importin) beta 1 (HGNC Symbol)

Entrez gene summary

 Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 47649476 - 47685505

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108424 (version 83.38)

Entrez gene

 3837

UniProt

 Q14974 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14974

Antibodypedia

 KPNB1 antibodies

PROTEIN BROWSER
KPNB1-001
KPNB1-002
KPNB1-003
KPNB1-004
KPNB1-005
KPNB1-007
KPNB1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KPNB1-001
ENSP00000290158
ENST00000290158
Q14974 [Direct mapping]
Importin subunit beta-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000060 [protein import into nucleus, translocation]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006606 [protein import into nucleus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007079 [mitotic chromosome movement towards spindle pole]
GO:0007080 [mitotic metaphase plate congression]
GO:0008139 [nuclear localization sequence binding]
GO:0008270 [zinc ion binding]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030953 [astral microtubule organization]
GO:0031291 [Ran protein signal transduction]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0040001 [establishment of mitotic spindle localization]
GO:0043234 [protein complex]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0070062 [extracellular exosome]
GO:0071782 [endoplasmic reticulum tubular network]
GO:0075733 [intracellular transport of virus]
GO:0090307 [mitotic spindle assembly]
Show all
 876 aa
97.2 kDa 		No 0
KPNB1-002
ENSP00000438253
ENST00000535458
Q14974 [Direct mapping]
Importin subunit beta-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000060 [protein import into nucleus, translocation]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006606 [protein import into nucleus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007079 [mitotic chromosome movement towards spindle pole]
GO:0007080 [mitotic metaphase plate congression]
GO:0008139 [nuclear localization sequence binding]
GO:0008270 [zinc ion binding]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030953 [astral microtubule organization]
GO:0031291 [Ran protein signal transduction]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0070062 [extracellular exosome]
GO:0071782 [endoplasmic reticulum tubular network]
GO:0075733 [intracellular transport of virus]
GO:0090307 [mitotic spindle assembly]
Show all
 731 aa
81.2 kDa 		No 0
KPNB1-003
ENSP00000438964
ENST00000540627
Q14974 [Direct mapping]
Importin subunit beta-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000060 [protein import into nucleus, translocation]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006606 [protein import into nucleus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007079 [mitotic chromosome movement towards spindle pole]
GO:0007080 [mitotic metaphase plate congression]
GO:0008139 [nuclear localization sequence binding]
GO:0008270 [zinc ion binding]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030953 [astral microtubule organization]
GO:0031291 [Ran protein signal transduction]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0040001 [establishment of mitotic spindle localization]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0070062 [extracellular exosome]
GO:0071782 [endoplasmic reticulum tubular network]
GO:0075733 [intracellular transport of virus]
GO:0090307 [mitotic spindle assembly]
Show all
 731 aa
81.2 kDa 		No 0
KPNB1-004
ENSP00000463066
ENST00000582097
J3KTM9 [Direct mapping]
Importin subunit beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
Show all
 690 aa
76.4 kDa 		No 0
KPNB1-005
ENSP00000464042
ENST00000583648
J3QR48 [Direct mapping]
Importin subunit beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 149 aa
16.5 kDa 		No 0
KPNB1-007
ENSP00000464200
ENST00000577875
J3QRG4 [Direct mapping]
Importin subunit beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 60 aa
6.7 kDa 		No 0
KPNB1-008
ENSP00000463190
ENST00000583013
J3QKQ5 [Direct mapping]
Importin subunit beta-1
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
Show all
 248 aa
27.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.