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GALK1

GENERAL INFORMATION

Gene name

 GALK1

Gene description

 Galactokinase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression. Highest expression in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA007094 , HPA016960
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GALK1 (HGNC Symbol)

Synonyms

 GALK

Description

 Galactokinase 1 (HGNC Symbol)

Entrez gene summary

 Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 75751594 - 75765711

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108479 (version 83.38)

Entrez gene

 2584

UniProt

 P51570 (UniProt - Evidence at protein level)

neXtProt

 NX_P51570

Antibodypedia

 GALK1 antibodies

PROTEIN BROWSER
GALK1-001
GALK1-002
GALK1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GALK1-001
ENSP00000465930
ENST00000588479
P51570 [Direct mapping]
Galactokinase
V9HWE7 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 19
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004335 [galactokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005534 [galactose binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006012 [galactose metabolic process]
GO:0016020 [membrane]
GO:0019388 [galactose catabolic process]
GO:0019402 [galactitol metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0070062 [extracellular exosome]
Show all
 392 aa
42.3 kDa 		No 0
GALK1-002
ENSP00000225614
ENST00000225614
P51570 [Direct mapping]
Galactokinase
V9HWE7 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 19
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004335 [galactokinase activity]
GO:0005524 [ATP binding]
GO:0005534 [galactose binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006012 [galactose metabolic process]
GO:0016020 [membrane]
GO:0019388 [galactose catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0070062 [extracellular exosome]
Show all
 392 aa
42.3 kDa 		No 0
GALK1-007
ENSP00000464765
ENST00000592997
K7EII7 [Direct mapping]
Galactokinase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 184 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.