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SLC6A4

GENERAL INFORMATION

Gene name

 SLC6A4

Gene description

 Solute carrier family 6 (neurotransmitter transporter), member 4

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (small intestine, lung, placenta, duodenum)
GTEx:Group enriched (lung, small intestine)
FANTOM5:Group enriched (lung, placenta)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, lung, placenta, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, placenta)

GENE INFORMATION

Gene name

 SLC6A4 (HGNC Symbol)

Synonyms

 5-HTT, HTT, OCD1, SERT1

Description

 Solute carrier family 6 (neurotransmitter transporter), member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 30194319 - 30236002

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108576 (version 83.38)

Entrez gene

 6532

UniProt

 P31645 (UniProt - Evidence at protein level)

neXtProt

 NX_P31645

Antibodypedia

 SLC6A4 antibodies

PROTEIN BROWSER
SLC6A4-001
SLC6A4-002
SLC6A4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC6A4-001
ENSP00000378298
ENST00000394821
J3KPR9 [Direct mapping]
Transporter
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005335 [serotonin:sodium symporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006836 [neurotransmitter transport]
GO:0006837 [serotonin transport]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 618 aa
69 kDa 		No >9
SLC6A4-002
ENSP00000385822
ENST00000401766
P31645 [Direct mapping]
Sodium-dependent serotonin transporter
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005335 [serotonin:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006836 [neurotransmitter transport]
GO:0006837 [serotonin transport]
GO:0007268 [synaptic transmission]
GO:0008504 [monoamine transmembrane transporter activity]
GO:0009636 [response to toxic substance]
GO:0010008 [endosome membrane]
GO:0012505 [endomembrane system]
GO:0015222 [serotonin transmembrane transporter activity]
GO:0015844 [monoamine transport]
GO:0016021 [integral component of membrane]
GO:0017137 [Rab GTPase binding]
GO:0021794 [thalamus development]
GO:0035176 [social behavior]
GO:0043005 [neuron projection]
GO:0045121 [membrane raft]
GO:0046621 [negative regulation of organ growth]
GO:0048854 [brain morphogenesis]
GO:0051015 [actin filament binding]
GO:0051259 [protein oligomerization]
GO:0051610 [serotonin uptake]
GO:0055085 [transmembrane transport]
Show all
 630 aa
70.3 kDa 		No >9
SLC6A4-201
ENSP00000261707
ENST00000261707
P31645 [Direct mapping]
Sodium-dependent serotonin transporter
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005335 [serotonin:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006836 [neurotransmitter transport]
GO:0006837 [serotonin transport]
GO:0007268 [synaptic transmission]
GO:0007420 [brain development]
GO:0007584 [response to nutrient]
GO:0007613 [memory]
GO:0007623 [circadian rhythm]
GO:0008504 [monoamine transmembrane transporter activity]
GO:0009636 [response to toxic substance]
GO:0010008 [endosome membrane]
GO:0010033 [response to organic substance]
GO:0010628 [positive regulation of gene expression]
GO:0012505 [endomembrane system]
GO:0015222 [serotonin transmembrane transporter activity]
GO:0015844 [monoamine transport]
GO:0016021 [integral component of membrane]
GO:0017022 [myosin binding]
GO:0017075 [syntaxin-1 binding]
GO:0017137 [Rab GTPase binding]
GO:0019811 [cocaine binding]
GO:0021794 [thalamus development]
GO:0021941 [negative regulation of cerebellar granule cell precursor proliferation]
GO:0032227 [negative regulation of synaptic transmission, dopaminergic]
GO:0032355 [response to estradiol]
GO:0035176 [social behavior]
GO:0042310 [vasoconstriction]
GO:0042493 [response to drug]
GO:0042713 [sperm ejaculation]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0045121 [membrane raft]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0046621 [negative regulation of organ growth]
GO:0048854 [brain morphogenesis]
GO:0050998 [nitric-oxide synthase binding]
GO:0051015 [actin filament binding]
GO:0051259 [protein oligomerization]
GO:0051260 [protein homooligomerization]
GO:0051610 [serotonin uptake]
GO:0055085 [transmembrane transport]
GO:0071300 [cellular response to retinoic acid]
GO:0071310 [cellular response to organic substance]
GO:0071321 [cellular response to cGMP]
Show all
 630 aa
70.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.