Cell atlas - NAGLU - The Human Protein Atlas

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NAGLU

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	NAGLU
Gene description	N-acetylglucosaminidase, alpha
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	NAGLU (HGNC Symbol)
Synonyms	NAG
Description	N-acetylglucosaminidase, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42536172 - 42544449
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108784 (version 83.38)
Entrez gene	4669
UniProt	P54802 (UniProt - Evidence at protein level)
neXtProt	NX_P54802
Antibodypedia	NAGLU antibodies

PROTEIN BROWSER

NAGLU-001	NAGLU-002	NAGLU-003	NAGLU-004	NAGLU-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAGLU-001 ENSP00000225927 ENST00000225927	P54802 [Direct mapping] Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase 82 kDa form Alpha-N-acetylglucosaminidase 77 kDa form Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004561 [alpha-N-acetylglucosaminidase activity] GO:0005764 [lysosome] GO:0005975 [carbohydrate metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0007040 [lysosome organization] GO:0007399 [nervous system development] GO:0021680 [cerebellar Purkinje cell layer development] GO:0030203 [glycosaminoglycan metabolic process] GO:0042474 [middle ear morphogenesis] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0045475 [locomotor rhythm] GO:0046548 [retinal rod cell development] GO:0060119 [inner ear receptor cell development] GO:0070062 [extracellular exosome] Show all	743 aa 82.3 kDa	Yes	0
NAGLU-002 ENSP00000467836 ENST00000591587	K7EQH9 [Direct mapping] Alpha-N-acetylglucosaminidase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.2 kDa	Yes	0
NAGLU-003 ENSP00000466892 ENST00000590358	K7END1 [Direct mapping] Alpha-N-acetylglucosaminidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 9.5 kDa	No	0
NAGLU-004 ENSP00000467135 ENST00000586516	K7ENX5 [Direct mapping] Alpha-N-acetylglucosaminidase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.5 kDa	Yes	0
NAGLU-005 ENSP00000468665 ENST00000592454	K7ESD7 [Direct mapping] Alpha-N-acetylglucosaminidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 6.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.