Tissue expression of NAGLU - Summary - The Human Protein Atlas

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NAGLU

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NAGLU
Gene description	N-acetylglucosaminidase, alpha
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA038815
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NAGLU (HGNC Symbol)
Synonyms	NAG
Description	N-acetylglucosaminidase, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42536172 - 42544449
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108784 (version 83.38)
Entrez gene	4669
UniProt	P54802 (UniProt - Evidence at protein level)
neXtProt	NX_P54802
Antibodypedia	NAGLU antibodies

PROTEIN BROWSER

NAGLU-001	NAGLU-002	NAGLU-003	NAGLU-004	NAGLU-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAGLU-001 ENSP00000225927 ENST00000225927	P54802 [Direct mapping] Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase 82 kDa form Alpha-N-acetylglucosaminidase 77 kDa form Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004561 [alpha-N-acetylglucosaminidase activity] GO:0005764 [lysosome] GO:0005975 [carbohydrate metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0007040 [lysosome organization] GO:0007399 [nervous system development] GO:0021680 [cerebellar Purkinje cell layer development] GO:0030203 [glycosaminoglycan metabolic process] GO:0042474 [middle ear morphogenesis] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0045475 [locomotor rhythm] GO:0046548 [retinal rod cell development] GO:0060119 [inner ear receptor cell development] GO:0070062 [extracellular exosome] Show all	743 aa 82.3 kDa	Yes	0
NAGLU-002 ENSP00000467836 ENST00000591587	K7EQH9 [Direct mapping] Alpha-N-acetylglucosaminidase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.2 kDa	Yes	0
NAGLU-003 ENSP00000466892 ENST00000590358	K7END1 [Direct mapping] Alpha-N-acetylglucosaminidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 9.5 kDa	No	0
NAGLU-004 ENSP00000467135 ENST00000586516	K7ENX5 [Direct mapping] Alpha-N-acetylglucosaminidase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.5 kDa	Yes	0
NAGLU-005 ENSP00000468665 ENST00000592454	K7ESD7 [Direct mapping] Alpha-N-acetylglucosaminidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 6.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.