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Cancer tissues showed weak to moderate cytoplasmic staining. A few cases of ovarian cancers displayed strong positivity. Lymphomas were weakly stained or generally negative.
Gliomas and breast cancers showed moderate nuclear and cytoplasmic stained. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
MLX (HGNC Symbol)
Synonyms
bHLHd13, MAD7, MXD7, TCFL4
Description
MLX, MAX dimerization protein (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006112 [energy reserve metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006913 [nucleocytoplasmic transport] GO:0008134 [transcription factor binding] GO:0031325 [positive regulation of cellular metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity]
Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006112 [energy reserve metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0031325 [positive regulation of cellular metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity]
Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006112 [energy reserve metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0031325 [positive regulation of cellular metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity]
