Cell atlas - MLX - The Human Protein Atlas

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MLX

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear membrane
	Nucleoplasm

Human cell
	Cytosol
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MLX
Gene description	MLX, MAX dimerization protein
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Additional location	In addition localized to the Nucleoplasm (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA064438
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane. In addition localized to the cytosol & nucleoplasm.

Main location

Nuclear membrane (approved)

Additional location

Nucleoplasm (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064438	MCF7	Nucleoplasm
			Nuclear membrane
			Cytosol
	HPA064438	RH-30	No staining
	HPA064438	U-2 OS	No staining

GENE INFORMATION
Gene name	MLX (HGNC Symbol)
Synonyms	bHLHd13, MAD7, MXD7, TCFL4
Description	MLX, MAX dimerization protein (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42567068 - 42573239
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108788 (version 83.38)
Entrez gene	6945
UniProt	Q9UH92 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UH92
Antibodypedia	MLX antibodies

PROTEIN BROWSER

MLX-001	MLX-002	MLX-003	MLX-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MLX-001 ENSP00000246912 ENST00000246912	Q9UH92 [Direct mapping] Max-like protein X Show all	Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006112 [energy reserve metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006913 [nucleocytoplasmic transport] GO:0008134 [transcription factor binding] GO:0031325 [positive regulation of cellular metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] Show all	298 aa 33.3 kDa	No	0
MLX-002 ENSP00000416627 ENST00000435881	Q9UH92 [Direct mapping] Max-like protein X Show all	Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006112 [energy reserve metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0031325 [positive regulation of cellular metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] Show all	244 aa 27.9 kDa	No	0
MLX-003 ENSP00000320913 ENST00000346833	Q9UH92 [Direct mapping] Max-like protein X Show all	Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006112 [energy reserve metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0031325 [positive regulation of cellular metabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] Show all	214 aa 24.9 kDa	No	0
MLX-008 ENSP00000464697 ENST00000591024	K7EID0 [Direct mapping] Max-like protein X Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046983 [protein dimerization activity] Show all	248 aa 28 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.