Expression of UNC119 in cancer - Summary

CANCER ATLAS

Gene description

Unc-119 lipid binding chaperone

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041912

GENE INFORMATION
Gene name	UNC119 (HGNC Symbol)
Synonyms	HRG4, POC7, POC7A
Description	Unc-119 lipid binding chaperone (HGNC Symbol)
Entrez gene summary	This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	28546707 - 28552668
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109103 (version 83.38)
Entrez gene	9094
UniProt	Q13432 (UniProt - Evidence at protein level)
neXtProt	NX_Q13432
Antibodypedia	UNC119 antibodies

PROTEIN BROWSER

UNC119-001	UNC119-002	UNC119-003	UNC119-004	UNC119-006	UNC119-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UNC119-001 ENSP00000337040 ENST00000335765	Q13432 [Direct mapping] Protein unc-119 homolog A Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006897 [endocytosis] GO:0007268 [synaptic transmission] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0008289 [lipid binding] GO:0042953 [lipoprotein transport] GO:0045171 [intercellular bridge] GO:0051233 [spindle midzone] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:1900186 [negative regulation of clathrin-mediated endocytosis] GO:2001287 [negative regulation of caveolin-mediated endocytosis] Show all	240 aa 27 kDa	No	0
UNC119-002 ENSP00000301032 ENST00000301032	Q13432 [Direct mapping] Protein unc-119 homolog A Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006897 [endocytosis] GO:0007268 [synaptic transmission] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0008289 [lipid binding] GO:0042953 [lipoprotein transport] GO:0045171 [intercellular bridge] GO:0051233 [spindle midzone] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:1900186 [negative regulation of clathrin-mediated endocytosis] GO:2001287 [negative regulation of caveolin-mediated endocytosis] Show all	220 aa 24.1 kDa	No	0
UNC119-003 ENSP00000465323 ENST00000470125	K7EJU3 [Direct mapping] Protein unc-119 homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.2 kDa	No	0
UNC119-004 ENSP00000466831 ENST00000484980	K7EN86 [Direct mapping] Protein unc-119 homolog A; Unc-119 homolog (C. elegans), isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 17.1 kDa	No	0
UNC119-006 ENSP00000414639 ENST00000444148	C9JSK0 [Direct mapping] Protein unc-119 homolog A Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		208 aa 22.7 kDa	No	0
UNC119-008 ENSP00000463893 ENST00000581945	J3QQT8 [Direct mapping] Protein unc-119 homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 8.4 kDa	No	0