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UNC119

GENERAL INFORMATION

Gene name

 UNC119

Gene description

 Unc-119 lipid binding chaperone

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in photoreceptor cells and outer plexiform layer in retina.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA041912
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinRetinaNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin01020304050TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0100200300400500600700Tags Per Million

GENE INFORMATION

Gene name

 UNC119 (HGNC Symbol)

Synonyms

 HRG4, POC7, POC7A

Description

 Unc-119 lipid binding chaperone (HGNC Symbol)

Entrez gene summary

 This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 28546707 - 28552668

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109103 (version 83.38)

Entrez gene

 9094

UniProt

 Q13432 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13432

Antibodypedia

 UNC119 antibodies

PROTEIN BROWSER
UNC119-001
UNC119-002
UNC119-003
UNC119-004
UNC119-006
UNC119-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UNC119-001
ENSP00000337040
ENST00000335765
Q13432 [Direct mapping]
Protein unc-119 homolog A
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006897 [endocytosis]
GO:0007268 [synaptic transmission]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0008289 [lipid binding]
GO:0042953 [lipoprotein transport]
GO:0045171 [intercellular bridge]
GO:0051233 [spindle midzone]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1900186 [negative regulation of clathrin-mediated endocytosis]
GO:2001287 [negative regulation of caveolin-mediated endocytosis]
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 240 aa
27 kDa 		No 0
UNC119-002
ENSP00000301032
ENST00000301032
Q13432 [Direct mapping]
Protein unc-119 homolog A
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006897 [endocytosis]
GO:0007268 [synaptic transmission]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0008289 [lipid binding]
GO:0042953 [lipoprotein transport]
GO:0045171 [intercellular bridge]
GO:0051233 [spindle midzone]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1900186 [negative regulation of clathrin-mediated endocytosis]
GO:2001287 [negative regulation of caveolin-mediated endocytosis]
Show all
 220 aa
24.1 kDa 		No 0
UNC119-003
ENSP00000465323
ENST00000470125
K7EJU3 [Direct mapping]
Protein unc-119 homolog A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 125 aa
14.2 kDa 		No 0
UNC119-004
ENSP00000466831
ENST00000484980
K7EN86 [Direct mapping]
Protein unc-119 homolog A; Unc-119 homolog (C. elegans), isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 145 aa
17.1 kDa 		No 0
UNC119-006
ENSP00000414639
ENST00000444148
C9JSK0 [Direct mapping]
Protein unc-119 homolog A
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 208 aa
22.7 kDa 		No 0
UNC119-008
ENSP00000463893
ENST00000581945
J3QQT8 [Direct mapping]
Protein unc-119 homolog A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 86 aa
8.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.