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NFKB1

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GENERAL INFORMATION

Gene name

 NFKB1

Gene description

 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Protein class

 Cancer-related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA027305
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA027305 A-431 Nucleoplasm
Cytosol
HPA027305 U-2 OS Nucleoplasm
Mitochondria
Cytosol
HPA027305 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 NFKB1 (HGNC Symbol)

Synonyms

 KBF1, NF-kappaB, NF-kB1, NFkappaB, NFKB-p50, p105, p50

Description

 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 4

Cytoband

 q24

Chromosome location (bp)

 102501329 - 102617302

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109320 (version 83.38)

Entrez gene

 4790

UniProt

 P19838 (UniProt - Evidence at protein level)

neXtProt

 NX_P19838

Antibodypedia

 NFKB1 antibodies

PROTEIN BROWSER
NFKB1-001
NFKB1-002
NFKB1-003
NFKB1-004
NFKB1-005
NFKB1-007
NFKB1-011
NFKB1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFKB1-001
ENSP00000226574
ENST00000226574
P19838 [Direct mapping]
Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001818 [negative regulation of cytokine production]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008134 [transcription factor binding]
GO:0009617 [response to bacterium]
GO:0010628 [positive regulation of gene expression]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010884 [positive regulation of lipid storage]
GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity]
GO:0010957 [negative regulation of vitamin D biosynthetic process]
GO:0014070 [response to organic cyclic compound]
GO:0031072 [heat shock protein binding]
GO:0031293 [membrane protein intracellular domain proteolysis]
GO:0032269 [negative regulation of cellular protein metabolic process]
GO:0032375 [negative regulation of cholesterol transport]
GO:0032481 [positive regulation of type I interferon production]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035994 [response to muscle stretch]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045083 [negative regulation of interleukin-12 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046688 [response to copper ion]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071316 [cellular response to nicotine]
GO:0071322 [cellular response to carbohydrate stimulus]
GO:0071347 [cellular response to interleukin-1]
GO:0071354 [cellular response to interleukin-6]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071359 [cellular response to dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1900127 [positive regulation of hyaluronan biosynthetic process]
GO:1901653 [cellular response to peptide]
GO:1904630 [cellular response to diterpene]
GO:1904632 [cellular response to glucoside]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 969 aa
105.4 kDa 		No 0
NFKB1-002
ENSP00000378297
ENST00000394820
P19838 [Direct mapping]
Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit
A0A024RDJ4 [Target identity:100%; Query identity:100%]
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (P105), isoform CRA_b
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008134 [transcription factor binding]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010884 [positive regulation of lipid storage]
GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity]
GO:0010957 [negative regulation of vitamin D biosynthetic process]
GO:0031293 [membrane protein intracellular domain proteolysis]
GO:0032269 [negative regulation of cellular protein metabolic process]
GO:0032375 [negative regulation of cholesterol transport]
GO:0032481 [positive regulation of type I interferon production]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042805 [actinin binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071316 [cellular response to nicotine]
GO:0071347 [cellular response to interleukin-1]
GO:0071354 [cellular response to interleukin-6]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1900127 [positive regulation of hyaluronan biosynthetic process]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 968 aa
105.4 kDa 		No 0
NFKB1-003
ENSP00000424790
ENST00000505458
P19838 [Direct mapping]
Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit
A0A024RDJ4 [Target identity:100%; Query identity:100%]
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (P105), isoform CRA_b
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008134 [transcription factor binding]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010884 [positive regulation of lipid storage]
GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity]
GO:0010957 [negative regulation of vitamin D biosynthetic process]
GO:0031293 [membrane protein intracellular domain proteolysis]
GO:0032269 [negative regulation of cellular protein metabolic process]
GO:0032375 [negative regulation of cholesterol transport]
GO:0032481 [positive regulation of type I interferon production]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042805 [actinin binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071316 [cellular response to nicotine]
GO:0071347 [cellular response to interleukin-1]
GO:0071354 [cellular response to interleukin-6]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1900127 [positive regulation of hyaluronan biosynthetic process]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 968 aa
105.4 kDa 		No 0
NFKB1-004
ENSP00000426147
ENST00000507079
D6RH30 [Direct mapping]
Nuclear factor NF-kappa-B p105 subunit
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0045087 [innate immune response]
Show all
 198 aa
21.9 kDa 		No 0
NFKB1-005
ENSP00000420904
ENST00000511926
D6RDI9 [Direct mapping]
Nuclear factor NF-kappa-B p105 subunit
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0045087 [innate immune response]
Show all
 74 aa
8.7 kDa 		No 0
NFKB1-007
ENSP00000423877
ENST00000509165
D6RC45 [Direct mapping]
Nuclear factor NF-kappa-B p105 subunit
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0045087 [innate immune response]
Show all
 145 aa
15.9 kDa 		No 0
NFKB1-011
ENSP00000424815
ENST00000508584
D6RF93 [Direct mapping]
Nuclear factor NF-kappa-B p105 subunit
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0045087 [innate immune response]
Show all
 196 aa
21.4 kDa 		No 0
NFKB1-013
ENSP00000469340
ENST00000600343
P19838 [Direct mapping]
Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008134 [transcription factor binding]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010884 [positive regulation of lipid storage]
GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity]
GO:0010957 [negative regulation of vitamin D biosynthetic process]
GO:0031293 [membrane protein intracellular domain proteolysis]
GO:0032269 [negative regulation of cellular protein metabolic process]
GO:0032375 [negative regulation of cholesterol transport]
GO:0032481 [positive regulation of type I interferon production]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042805 [actinin binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071316 [cellular response to nicotine]
GO:0071347 [cellular response to interleukin-1]
GO:0071354 [cellular response to interleukin-6]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1900127 [positive regulation of hyaluronan biosynthetic process]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 788 aa
85.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.