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A majority of colorectal and prostate cancers as well as several endometrial and breast cancers displayed moderate immunoreactivity. Malignant cells in general were weakly stained or negative.
GENE INFORMATION
Gene name
IL2 (HGNC Symbol)
Synonyms
IL-2, TCGF
Description
Interleukin 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]