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IL2

GENERAL INFORMATION

Gene name

 IL2

Gene description

 Interleukin 2

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
CAB010310
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 IL2 (HGNC Symbol)

Synonyms

 IL-2, TCGF

Description

 Interleukin 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q27

Chromosome location (bp)

 122451470 - 122456725

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109471 (version 83.38)

Entrez gene

 3558

UniProt

 P60568 (UniProt - Evidence at protein level)

neXtProt

 NX_P60568

Antibodypedia

 IL2 antibodies

PROTEIN BROWSER
IL2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL2-001
ENSP00000226730
ENST00000226730
P60568 [Direct mapping]
Interleukin-2
Q0GK43 [Target identity:100%; Query identity:100%]
Interleukin 2; Interleukin-2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Candidate cardiovascular disease genes
Disease related genes
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002250 [adaptive immune response]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0005125 [cytokine activity]
GO:0005134 [interleukin-2 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019209 [kinase activator activity]
GO:0030101 [natural killer cell activation]
GO:0030217 [T cell differentiation]
GO:0030246 [carbohydrate binding]
GO:0030307 [positive regulation of cell growth]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031851 [kappa-type opioid receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0034105 [positive regulation of tissue remodeling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0043066 [negative regulation of apoptotic process]
GO:0043208 [glycosphingolipid binding]
GO:0045087 [innate immune response]
GO:0045471 [response to ethanol]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0045822 [negative regulation of heart contraction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046013 [regulation of T cell homeostatic proliferation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048304 [positive regulation of isotype switching to IgG isotypes]
GO:0050672 [negative regulation of lymphocyte proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0060999 [positive regulation of dendritic spine development]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
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 153 aa
17.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.