Expression of SOD3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Superoxide dismutase 3, extracellular

Protein class

Enzymes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042110

GENE INFORMATION
Gene name	SOD3 (HGNC Symbol)
Synonyms	EC-SOD
Description	Superoxide dismutase 3, extracellular (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
Chromosome	4
Cytoband	p15.2
Chromosome location (bp)	24789912 - 24800842
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109610 (version 83.38)
Entrez gene	6649
UniProt	P08294 (UniProt - Evidence at protein level)
neXtProt	NX_P08294
Antibodypedia	SOD3 antibodies

PROTEIN BROWSER

SOD3-001	SOD3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SOD3-001 ENSP00000371554 ENST00000382120	P08294 [Direct mapping] Extracellular superoxide dismutase [Cu-Zn] Show all	Enzymes ENZYME proteins Oxidoreductases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0001666 [response to hypoxia] GO:0004784 [superoxide dismutase activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005802 [trans-Golgi network] GO:0006801 [superoxide metabolic process] GO:0006979 [response to oxidative stress] GO:0008201 [heparin binding] GO:0008270 [zinc ion binding] GO:0019430 [removal of superoxide radicals] GO:0031012 [extracellular matrix] GO:0046688 [response to copper ion] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	240 aa 25.9 kDa	Yes	0
SOD3-002 ENSP00000472134 ENST00000598411	M0R1V4 [Direct mapping] Extracellular superoxide dismutase [Cu-Zn] Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005507 [copper ion binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0019430 [removal of superoxide radicals] Show all	54 aa 6 kDa	Yes	0