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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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SOD3
  • premium

    TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Superoxide dismutase 3, extracellular

Protein class

Enzymes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA042110

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Follicular adenoma carcinoma of thyroid showed strong cytoplasmic staining. Occasional cases of cholangiocarcinoma, prostate, endometrial and pancreatic cancers exhibited moderate to strong positivity. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

SOD3 (HGNC Symbol)

Synonyms

EC-SOD

Description

Superoxide dismutase 3, extracellular (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

Chromosome

4

Cytoband

p15.2

Chromosome location (bp)

24789912 - 24800842

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109610 (version 83.38)

Entrez gene

6649

UniProt

P08294 (UniProt - Evidence at protein level)

neXtProt

NX_P08294

Antibodypedia

SOD3 antibodies

PROTEIN BROWSER

SOD3-001
SOD3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOD3-001
ENSP00000371554
ENST00000382120
P08294 [Direct mapping]
Extracellular superoxide dismutase [Cu-Zn]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001666 [response to hypoxia]
GO:0004784 [superoxide dismutase activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005802 [trans-Golgi network]
GO:0006801 [superoxide metabolic process]
GO:0006979 [response to oxidative stress]
GO:0008201 [heparin binding]
GO:0008270 [zinc ion binding]
GO:0019430 [removal of superoxide radicals]
GO:0031012 [extracellular matrix]
GO:0046688 [response to copper ion]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
240 aa
25.9 kDa
Yes 0
SOD3-002
ENSP00000472134
ENST00000598411
M0R1V4 [Direct mapping]
Extracellular superoxide dismutase [Cu-Zn]
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0019430 [removal of superoxide radicals]
Show all
54 aa
6 kDa
Yes 0

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