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SOD3

GENERAL INFORMATION

Gene name

 SOD3

Gene description

 Superoxide dismutase 3, extracellular

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues with distinct positivity in plasma extracellular matrix.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA042110
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SOD3 (HGNC Symbol)

Synonyms

 EC-SOD

Description

 Superoxide dismutase 3, extracellular (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

Chromosome

 4

Cytoband

 p15.2

Chromosome location (bp)

 24789912 - 24800842

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109610 (version 83.38)

Entrez gene

 6649

UniProt

 P08294 (UniProt - Evidence at protein level)

neXtProt

 NX_P08294

Antibodypedia

 SOD3 antibodies

PROTEIN BROWSER
SOD3-001
SOD3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOD3-001
ENSP00000371554
ENST00000382120
P08294 [Direct mapping]
Extracellular superoxide dismutase [Cu-Zn]
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001666 [response to hypoxia]
GO:0004784 [superoxide dismutase activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005802 [trans-Golgi network]
GO:0006801 [superoxide metabolic process]
GO:0006979 [response to oxidative stress]
GO:0008201 [heparin binding]
GO:0008270 [zinc ion binding]
GO:0019430 [removal of superoxide radicals]
GO:0031012 [extracellular matrix]
GO:0046688 [response to copper ion]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 240 aa
25.9 kDa 		Yes 0
SOD3-002
ENSP00000472134
ENST00000598411
M0R1V4 [Direct mapping]
Extracellular superoxide dismutase [Cu-Zn]
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0019430 [removal of superoxide radicals]
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 54 aa
6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.