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CRYAB

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GENERAL INFORMATION

Gene name

 CRYAB

Gene description

 Crystallin, alpha B

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 16
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cytoplasm.

RNA cell category

 Cell line enhanced (U-138 MG, LHCN-M2, U-2 OS)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (validated), Cytosol (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB002053 , CAB040560
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-138 MG, LHCN-M2, U-2 OS)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cytoplasm.

Main location

 Plasma membrane (validated), Cytosol (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB002053 A-431 No staining    
CAB002053 U-2 OS Plasma membrane Intensity
Cytosol Intensity
CAB002053 U-251 MG Plasma membrane Intensity
Cytosol Intensity
CAB040560 A-431 No staining    
CAB040560 U-2 OS Plasma membrane Intensity
Cytosol Intensity
CAB040560 U-251 MG Plasma membrane Intensity
Cytosol Intensity

GENE INFORMATION

Gene name

 CRYAB (HGNC Symbol)

Synonyms

 CRYA2, HSPB5

Description

 Crystallin, alpha B (HGNC Symbol)

Entrez gene summary

 Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 11

Cytoband

 q23.1

Chromosome location (bp)

 111908565 - 111923722

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109846 (version 83.38)

Entrez gene

 1410

UniProt

 P02511 (UniProt - Evidence at protein level)

neXtProt

 NX_P02511

Antibodypedia

 CRYAB antibodies

PROTEIN BROWSER
«
CRYAB-001
CRYAB-002
CRYAB-003
CRYAB-004
CRYAB-005
CRYAB-006
CRYAB-007
CRYAB-008
CRYAB-009
CRYAB-010
CRYAB-011
CRYAB-012
CRYAB-013
CRYAB-014
CRYAB-015
CRYAB-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRYAB-001
ENSP00000436051
ENST00000526180
P02511 [Direct mapping]
Alpha-crystallin B chain
V9HW27 [Target identity:100%; Query identity:100%]
Crystallin, alpha B, isoform CRA_a; Epididymis secretory protein Li 101
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006936 [muscle contraction]
GO:0010941 [regulation of cell death]
GO:0032387 [negative regulation of intracellular transport]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0071480 [cellular response to gamma radiation]
Show all
 175 aa
20.2 kDa 		No 0
CRYAB-002
ENSP00000433560
ENST00000533475
P02511 [Direct mapping]
Alpha-crystallin B chain
V9HW27 [Target identity:100%; Query identity:100%]
Crystallin, alpha B, isoform CRA_a; Epididymis secretory protein Li 101
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0002088 [lens development in camera-type eye]
GO:0005212 [structural constituent of eye lens]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006936 [muscle contraction]
GO:0007021 [tubulin complex assembly]
GO:0007517 [muscle organ development]
GO:0007568 [aging]
GO:0008017 [microtubule binding]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0010629 [negative regulation of gene expression]
GO:0010941 [regulation of cell death]
GO:0015630 [microtubule cytoskeleton]
GO:0030018 [Z disc]
GO:0030308 [negative regulation of cell growth]
GO:0031109 [microtubule polymerization or depolymerization]
GO:0031674 [I band]
GO:0032355 [response to estradiol]
GO:0032387 [negative regulation of intracellular transport]
GO:0032432 [actin filament bundle]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043209 [myelin sheath]
GO:0043292 [contractile fiber]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
GO:0051260 [protein homooligomerization]
GO:0051403 [stress-activated MAPK cascade]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071480 [cellular response to gamma radiation]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 175 aa
20.2 kDa 		No 0
CRYAB-003
ENSP00000227251
ENST00000227251
P02511 [Direct mapping]
Alpha-crystallin B chain
V9HW27 [Target identity:100%; Query identity:100%]
Crystallin, alpha B, isoform CRA_a; Epididymis secretory protein Li 101
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006936 [muscle contraction]
GO:0010941 [regulation of cell death]
GO:0032387 [negative regulation of intracellular transport]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0071480 [cellular response to gamma radiation]
Show all
 175 aa
20.2 kDa 		No 0
CRYAB-004
ENSP00000434269
ENST00000533971
E9PRA8 [Direct mapping]
Alpha-crystallin B chain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
GO:0046872 [metal ion binding]
Show all
 155 aa
17.9 kDa 		No 1
CRYAB-005
ENSP00000436089
ENST00000527899
E9PR44 [Direct mapping]
Alpha-crystallin B chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
Show all
 174 aa
20 kDa 		No 0
CRYAB-006
ENSP00000435931
ENST00000533879
E9PRS4 [Direct mapping]
Alpha-crystallin B chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
Show all
 69 aa
8.2 kDa 		No 0
CRYAB-007
ENSP00000432182
ENST00000528628
E9PS12 [Direct mapping]
Alpha-crystallin B chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
Show all
 77 aa
9.2 kDa 		No 0
CRYAB-008
ENSP00000435411
ENST00000525823
A0A024R3B9 [Direct mapping]
Alpha-crystallin B chain; Crystallin, alpha B, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
Show all
 108 aa
12.3 kDa 		No 0
CRYAB-009
ENSP00000435960
ENST00000528961
A0A024R3B9 [Direct mapping]
Alpha-crystallin B chain; Crystallin, alpha B, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
Show all
 108 aa
12.3 kDa 		No 0
CRYAB-010
ENSP00000434793
ENST00000526167
E9PNH7 [Direct mapping]
Alpha-crystallin B chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
Show all
 106 aa
12 kDa 		No 0
CRYAB-011
ENSP00000435046
ENST00000533280
A0A024R3B9 [Direct mapping]
Alpha-crystallin B chain; Crystallin, alpha B, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
Show all
 108 aa
12.3 kDa 		No 0
CRYAB-012
ENSP00000432454
ENST00000524660
H0YCW8 [Direct mapping]
Alpha-crystallin B chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
Show all
 106 aa
11.7 kDa 		No 0
CRYAB-013
ENSP00000437149
ENST00000527950
P02511 [Direct mapping]
Alpha-crystallin B chain
V9HW27 [Target identity:100%; Query identity:100%]
Crystallin, alpha B, isoform CRA_a; Epididymis secretory protein Li 101
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006936 [muscle contraction]
GO:0010941 [regulation of cell death]
GO:0032387 [negative regulation of intracellular transport]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0071480 [cellular response to gamma radiation]
Show all
 175 aa
20.2 kDa 		No 0
CRYAB-014
ENSP00000431754
ENST00000529647
E9PJL7 [Direct mapping]
Alpha-crystallin B chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
Show all
 130 aa
15.4 kDa 		No 0
CRYAB-015
ENSP00000434247
ENST00000531198
P02511 [Direct mapping]
Alpha-crystallin B chain
V9HW27 [Target identity:100%; Query identity:100%]
Crystallin, alpha B, isoform CRA_a; Epididymis secretory protein Li 101
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006936 [muscle contraction]
GO:0010941 [regulation of cell death]
GO:0032387 [negative regulation of intracellular transport]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0071480 [cellular response to gamma radiation]
Show all
 175 aa
20.2 kDa 		No 0
CRYAB-201
ENSP00000483554
ENST00000616970
P02511 [Direct mapping]
Alpha-crystallin B chain
V9HW27 [Target identity:100%; Query identity:100%]
Crystallin, alpha B, isoform CRA_a; Epididymis secretory protein Li 101
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005212 [structural constituent of eye lens]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006936 [muscle contraction]
GO:0010941 [regulation of cell death]
GO:0032387 [negative regulation of intracellular transport]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0071480 [cellular response to gamma radiation]
Show all
 175 aa
20.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.