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ZBTB16

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GENERAL INFORMATION

Gene name

 ZBTB16

Gene description

 Zinc finger and BTB domain containing 16

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HEL, ASC TERT1, hTCEpi, AF22)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, ASC TERT1, hTCEpi, AF22)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ZBTB16 (HGNC Symbol)

Synonyms

 PLZF, ZNF145

Description

 Zinc finger and BTB domain containing 16 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q23.2

Chromosome location (bp)

 114059593 - 114250676

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109906 (version 83.38)

Entrez gene

 7704

UniProt

 Q05516 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05516

Antibodypedia

 ZBTB16 antibodies

PROTEIN BROWSER
ZBTB16-001
ZBTB16-003
ZBTB16-004
ZBTB16-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZBTB16-001
ENSP00000338157
ENST00000335953
Q05516 [Direct mapping]
Zinc finger and BTB domain-containing protein 16
A0A024R3C6 [Target identity:100%; Query identity:100%]
Zinc finger and BTB domain containing 16, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001501 [skeletal system development]
GO:0001823 [mesonephros development]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007417 [central nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009880 [embryonic pattern specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0016567 [protein ubiquitination]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0017053 [transcriptional repressor complex]
GO:0019904 [protein domain specific binding]
GO:0030097 [hemopoiesis]
GO:0030099 [myeloid cell differentiation]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0034504 [protein localization to nucleus]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035136 [forelimb morphogenesis]
GO:0035137 [hindlimb morphogenesis]
GO:0042733 [embryonic digit morphogenesis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045778 [positive regulation of ossification]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048133 [male germ-line stem cell asymmetric division]
GO:0051138 [positive regulation of NK T cell differentiation]
GO:0051216 [cartilage development]
GO:0061036 [positive regulation of cartilage development]
Show all
 673 aa
74.3 kDa 		No 0
ZBTB16-003
ENSP00000376721
ENST00000392996
Q05516 [Direct mapping]
Zinc finger and BTB domain-containing protein 16
A0A024R3C6 [Target identity:100%; Query identity:100%]
Zinc finger and BTB domain containing 16, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001823 [mesonephros development]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007417 [central nervous system development]
GO:0016567 [protein ubiquitination]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0017053 [transcriptional repressor complex]
GO:0030097 [hemopoiesis]
GO:0030099 [myeloid cell differentiation]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045778 [positive regulation of ossification]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0061036 [positive regulation of cartilage development]
Show all
 673 aa
74.3 kDa 		No 0
ZBTB16-004
ENSP00000437716
ENST00000544220
F5H6C3 [Direct mapping]
Zinc finger and BTB domain-containing protein 16
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 115 aa
13.2 kDa 		No 0
ZBTB16-005
ENSP00000443013
ENST00000535700
F5H5Y7 [Direct mapping]
Zinc finger and BTB domain-containing protein 16
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 148 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.