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Zinc finger and BTB domain containing 16 (HGNC Symbol)
Entrez gene summary
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Q05516 [Direct mapping] Zinc finger and BTB domain-containing protein 16 A0A024R3C6 [Target identity:100%; Query identity:100%] Zinc finger and BTB domain containing 16, isoform CRA_a
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001501 [skeletal system development] GO:0001823 [mesonephros development] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007417 [central nervous system development] GO:0008022 [protein C-terminus binding] GO:0008285 [negative regulation of cell proliferation] GO:0009880 [embryonic pattern specification] GO:0009952 [anterior/posterior pattern specification] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0016607 [nuclear speck] GO:0017053 [transcriptional repressor complex] GO:0019904 [protein domain specific binding] GO:0030097 [hemopoiesis] GO:0030099 [myeloid cell differentiation] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0034504 [protein localization to nucleus] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035136 [forelimb morphogenesis] GO:0035137 [hindlimb morphogenesis] GO:0042733 [embryonic digit morphogenesis] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045778 [positive regulation of ossification] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048133 [male germ-line stem cell asymmetric division] GO:0051138 [positive regulation of NK T cell differentiation] GO:0051216 [cartilage development] GO:0061036 [positive regulation of cartilage development]
Q05516 [Direct mapping] Zinc finger and BTB domain-containing protein 16 A0A024R3C6 [Target identity:100%; Query identity:100%] Zinc finger and BTB domain containing 16, isoform CRA_a
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001823 [mesonephros development] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007417 [central nervous system development] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0016607 [nuclear speck] GO:0017053 [transcriptional repressor complex] GO:0030097 [hemopoiesis] GO:0030099 [myeloid cell differentiation] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045600 [positive regulation of fat cell differentiation] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045778 [positive regulation of ossification] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0051216 [cartilage development] GO:0061036 [positive regulation of cartilage development]
F5H6C3 [Direct mapping] Zinc finger and BTB domain-containing protein 16
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
F5H5Y7 [Direct mapping] Zinc finger and BTB domain-containing protein 16
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)