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A few gliomas showed strong cytoplasmic positivity and a majority of prostate cancers and carcinoids were moderately stained. Remaining cancers were essentially negative.
Moderate to strong cytoplasmic positivity was displayed in prostate cancers, gliomas and carcinoids. Other cancers were essentially negative.
GENE INFORMATION
Gene name
B3GAT1 (HGNC Symbol)
Synonyms
CD57, GlcAT-P, HNK-1, LEU7, NK-1
Description
Beta-1,3-glucuronyltransferase 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
