Tissue expression of B3GAT1 - Summary - The Human Protein Atlas

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B3GAT1

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	B3GAT1
Gene description	Beta-1,3-glucuronyltransferase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (hippocampus, cerebral cortex, caudate, hypothalamus, stomach, cerebellum)
FANTOM5:	Tissue enhanced (hippocampus, caudate, brain)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression most abundant in CNS, peripheral nerves and neuroendocrine cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. CAB002500 , CAB010893
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, cerebral cortex, caudate, hypothalamus, stomach, cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus, caudate, brain)

GENE INFORMATION
Gene name	B3GAT1 (HGNC Symbol)
Synonyms	CD57, GlcAT-P, HNK-1, LEU7, NK-1
Description	Beta-1,3-glucuronyltransferase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q25
Chromosome location (bp)	134378504 - 134411918
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109956 (version 83.38)
Entrez gene	27087
UniProt	Q9P2W7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2W7
Antibodypedia	B3GAT1 antibodies

PROTEIN BROWSER

B3GAT1-001	B3GAT1-002	B3GAT1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B3GAT1-001 ENSP00000307875 ENST00000312527	Q9P2W7 [Direct mapping] Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Show all	GO:0000139 [Golgi membrane] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0015018 [galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050650 [chondroitin sulfate proteoglycan biosynthetic process] Show all	334 aa 38.3 kDa	No	0
B3GAT1-002 ENSP00000433847 ENST00000524765	Q9P2W7 [Direct mapping] Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Show all	GO:0000139 [Golgi membrane] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0008499 [UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity] GO:0015018 [galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050650 [chondroitin sulfate proteoglycan biosynthetic process] Show all	334 aa 38.3 kDa	No	0
B3GAT1-201 ENSP00000376359 ENST00000392580	Q9P2W7 [Direct mapping] Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Show all	GO:0000139 [Golgi membrane] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0015018 [galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050650 [chondroitin sulfate proteoglycan biosynthetic process] Show all	334 aa 38.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.