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LPXN

GENERAL INFORMATION

Gene name

 LPXN

Gene description

 Leupaxin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA043741 , CAB046478
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LPXN (HGNC Symbol)

Synonyms

 LDPL

Description

 Leupaxin (HGNC Symbol)

Entrez gene summary

 The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 58526871 - 58578220

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110031 (version 83.38)

Entrez gene

 9404

UniProt

 O60711 (UniProt - Evidence at protein level)

neXtProt

 NX_O60711

Antibodypedia

 LPXN antibodies

PROTEIN BROWSER
LPXN-001
LPXN-002
LPXN-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LPXN-001
ENSP00000461855
ENST00000528489
B7Z5P7 [Direct mapping]
Leupaxin; cDNA FLJ51550, highly similar to Leupaxin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
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 366 aa
41.6 kDa 		No 0
LPXN-002
ENSP00000378512
ENST00000395074
O60711 [Direct mapping]
Leupaxin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0007155 [cell adhesion]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0042995 [cell projection]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050859 [negative regulation of B cell receptor signaling pathway]
Show all
 386 aa
43.3 kDa 		No 0
LPXN-003
ENSP00000431284
ENST00000528954
O60711 [Direct mapping]
Leupaxin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0007155 [cell adhesion]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0042995 [cell projection]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050859 [negative regulation of B cell receptor signaling pathway]
Show all
 391 aa
43.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.