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EHD1

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GENERAL INFORMATION

Gene name

 EHD1

Gene description

 EH-domain containing 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA066751 , HPA067747
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA066751 BJ Plasma membrane
HPA066751 SiHa Plasma membrane
HPA066751 U-2 OS Plasma membrane
HPA067747 A-431 Plasma membrane
HPA067747 A549 Plasma membrane
HPA067747 U-2 OS Plasma membrane

GENE INFORMATION

Gene name

 EHD1 (HGNC Symbol)

Synonyms

 FLJ42622, FLJ44618, H-PAST, HPAST1, PAST1

Description

 EH-domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64851642 - 64888296

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110047 (version 83.38)

Entrez gene

 10938

UniProt

 Q9H4M9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4M9

Antibodypedia

 EHD1 antibodies

PROTEIN BROWSER
EHD1-001
EHD1-002
EHD1-007
EHD1-008
EHD1-013
EHD1-015
EHD1-016
EHD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EHD1-001
ENSP00000320516
ENST00000320631
Q9H4M9 [Direct mapping]
EH domain-containing protein 1
B2R5U3 [Target identity:100%; Query identity:100%]
EH-domain containing 1, isoform CRA_b; cDNA FLJ40523 fis, clone TESTI2046872, highly similar to EH-domain-containing protein 1; cDNA, FLJ92624, highly similar to Homo sapiens EH-domain containing 1 (EHD1), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007596 [blood coagulation]
GO:0010008 [endosome membrane]
GO:0010886 [positive regulation of cholesterol storage]
GO:0016020 [membrane]
GO:0017137 [Rab GTPase binding]
GO:0020018 [ciliary pocket membrane]
GO:0031095 [platelet dense tubular network membrane]
GO:0031175 [neuron projection development]
GO:0031901 [early endosome membrane]
GO:0032456 [endocytic recycling]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0042384 [cilium assembly]
GO:0042632 [cholesterol homeostasis]
GO:0051260 [protein homooligomerization]
GO:0055038 [recycling endosome membrane]
GO:0061512 [protein localization to cilium]
GO:0070062 [extracellular exosome]
GO:1901741 [positive regulation of myoblast fusion]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:2001137 [positive regulation of endocytic recycling]
Show all
 534 aa
60.6 kDa 		No 0
EHD1-002
ENSP00000352354
ENST00000359393
Q9H4M9 [Direct mapping]
EH domain-containing protein 1
B2R5U3 [Target identity:100%; Query identity:100%]
EH-domain containing 1, isoform CRA_b; cDNA FLJ40523 fis, clone TESTI2046872, highly similar to EH-domain-containing protein 1; cDNA, FLJ92624, highly similar to Homo sapiens EH-domain containing 1 (EHD1), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007596 [blood coagulation]
GO:0010008 [endosome membrane]
GO:0010886 [positive regulation of cholesterol storage]
GO:0016020 [membrane]
GO:0017137 [Rab GTPase binding]
GO:0020018 [ciliary pocket membrane]
GO:0031095 [platelet dense tubular network membrane]
GO:0031175 [neuron projection development]
GO:0031901 [early endosome membrane]
GO:0032456 [endocytic recycling]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0042384 [cilium assembly]
GO:0042632 [cholesterol homeostasis]
GO:0051260 [protein homooligomerization]
GO:0055038 [recycling endosome membrane]
GO:0061512 [protein localization to cilium]
GO:0070062 [extracellular exosome]
GO:1901741 [positive regulation of myoblast fusion]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:2001137 [positive regulation of endocytic recycling]
Show all
 534 aa
60.6 kDa 		No 0
EHD1-007
ENSP00000404944
ENST00000433803
C9JC03 [Direct mapping]
EH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0032456 [endocytic recycling]
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 374 aa
42.7 kDa 		No 0
EHD1-008
ENSP00000391429
ENST00000421510
C9J2Z4 [Direct mapping]
EH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0032456 [endocytic recycling]
Show all
 306 aa
34.7 kDa 		No 0
EHD1-013
ENSP00000396273
ENST00000455148
C9JDQ8 [Direct mapping]
EH domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0032456 [endocytic recycling]
Show all
 162 aa
18.6 kDa 		No 0
EHD1-015
ENSP00000403830
ENST00000411683
C9JIJ3 [Direct mapping]
EH domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0032456 [endocytic recycling]
Show all
 145 aa
16.6 kDa 		No 0
EHD1-016
ENSP00000399022
ENST00000457202
C9IZH1 [Direct mapping]
EH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0032456 [endocytic recycling]
Show all
 148 aa
16.9 kDa 		No 0
EHD1-201
ENSP00000479153
ENST00000621096
A0A024R571 [Direct mapping]
EH domain-containing protein 1; EH-domain containing 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0010008 [endosome membrane]
GO:0010886 [positive regulation of cholesterol storage]
GO:0016197 [endosomal transport]
GO:0030139 [endocytic vesicle]
GO:0031095 [platelet dense tubular network membrane]
GO:0031175 [neuron projection development]
GO:0032456 [endocytic recycling]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0042632 [cholesterol homeostasis]
GO:0043209 [myelin sheath]
GO:0048471 [perinuclear region of cytoplasm]
GO:1901741 [positive regulation of myoblast fusion]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:2001137 [positive regulation of endocytic recycling]
Show all
 548 aa
61.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.