Cell atlas - PUS3 - The Human Protein Atlas

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PUS3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PUS3
Gene description	Pseudouridylate synthase 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA038040 , HPA063802
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (approved)

Additional location

Cytosol (approved)


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Antibody	Cell line	Location
HPA038040	A-431	Nucleus
HPA038040	A-431	Cytosol
HPA038040	U-2 OS	No staining
HPA038040	U-251 MG	No staining
HPA063802	PC-3	Nucleoplasm
HPA063802	RH-30	No staining
HPA063802	U-2 OS	No staining

GENE INFORMATION
Gene name	PUS3 (HGNC Symbol)
Synonyms	FKSG32
Description	Pseudouridylate synthase 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the formation of tRNA pseudouridine from tRNA uridine at position 39 in the anticodon stem and loop of transfer RNAs. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125893485 - 125903221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110060 (version 83.38)
Entrez gene	83480
UniProt	Q9BZE2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZE2
Antibodypedia	PUS3 antibodies

PROTEIN BROWSER

PUS3-001	PUS3-002	PUS3-003	PUS3-201	PUS3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PUS3-001 ENSP00000432386 ENST00000530811	Q9BZE2 [Direct mapping] tRNA pseudouridine(38/39) synthase Show all	Enzymes ENZYME proteins Isomerase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	481 aa 55.6 kDa	No	0
PUS3-002 ENSP00000432272 ENST00000534158	E9PRI9 [Direct mapping] tRNA pseudouridine synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	169 aa 19.5 kDa	No	0
PUS3-003 ENSP00000437077 ENST00000529801	E9PNY6 [Direct mapping] tRNA pseudouridine(38/39) synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	105 aa 12.2 kDa	No	0
PUS3-201 ENSP00000227474 ENST00000227474	Q9BZE2 [Direct mapping] tRNA pseudouridine(38/39) synthase Show all	Enzymes ENZYME proteins Isomerase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] GO:0031119 [tRNA pseudouridine synthesis] Show all	481 aa 55.6 kDa	No	0
PUS3-202 ENSP00000481536 ENST00000613398	A0A087WY59 [Direct mapping] tRNA pseudouridine synthase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	273 aa 31.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.