Tissue expression of PUS3 - Summary - The Human Protein Atlas

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PUS3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PUS3
Gene description	Pseudouridylate synthase 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA038040
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PUS3 (HGNC Symbol)
Synonyms	FKSG32
Description	Pseudouridylate synthase 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the formation of tRNA pseudouridine from tRNA uridine at position 39 in the anticodon stem and loop of transfer RNAs. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125893485 - 125903221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110060 (version 83.38)
Entrez gene	83480
UniProt	Q9BZE2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZE2
Antibodypedia	PUS3 antibodies

PROTEIN BROWSER

PUS3-001	PUS3-002	PUS3-003	PUS3-201	PUS3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PUS3-001 ENSP00000432386 ENST00000530811	Q9BZE2 [Direct mapping] tRNA pseudouridine(38/39) synthase Show all	Enzymes ENZYME proteins Isomerase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	481 aa 55.6 kDa	No	0
PUS3-002 ENSP00000432272 ENST00000534158	E9PRI9 [Direct mapping] tRNA pseudouridine synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	169 aa 19.5 kDa	No	0
PUS3-003 ENSP00000437077 ENST00000529801	E9PNY6 [Direct mapping] tRNA pseudouridine(38/39) synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	105 aa 12.2 kDa	No	0
PUS3-201 ENSP00000227474 ENST00000227474	Q9BZE2 [Direct mapping] tRNA pseudouridine(38/39) synthase Show all	Enzymes ENZYME proteins Isomerase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] GO:0031119 [tRNA pseudouridine synthesis] Show all	481 aa 55.6 kDa	No	0
PUS3-202 ENSP00000481536 ENST00000613398	A0A087WY59 [Direct mapping] tRNA pseudouridine synthase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	273 aa 31.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.