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APOA4

GENERAL INFORMATION

Gene name

 APOA4

Gene description

 Apolipoprotein A-IV

Protein class

 Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (small intestine, duodenum)
GTEx:Tissue enriched (small intestine)
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 High expression in small intestine and distinct positivity in plasma.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 5 antibodies.
HPA001352 , HPA002549 , CAB068250 , CAB068251 , CAB068252
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

 APOA4

Synonyms

Description

 Apolipoprotein A-IV (HGNC Symbol)

Entrez gene summary

 Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 116820700 - 116823306

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110244 (version 83.38)

Entrez gene

 337

UniProt

 P06727 (UniProt - Evidence at protein level)

neXtProt

 NX_P06727

Antibodypedia

 APOA4 antibodies

PROTEIN BROWSER
APOA4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOA4-001
ENSP00000350425
ENST00000357780
P06727 [Direct mapping]
Apolipoprotein A-IV
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001523 [retinoid metabolic process]
GO:0002227 [innate immune response in mucosa]
GO:0005319 [lipid transporter activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0006982 [response to lipid hydroperoxide]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007603 [phototransduction, visible light]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0009986 [cell surface]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0015485 [cholesterol binding]
GO:0016209 [antioxidant activity]
GO:0017127 [cholesterol transporter activity]
GO:0019430 [removal of superoxide radicals]
GO:0019433 [triglyceride catabolic process]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0031102 [neuron projection regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0032374 [regulation of cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034371 [chylomicron remodeling]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034378 [chylomicron assembly]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034445 [negative regulation of plasma lipoprotein particle oxidation]
GO:0035634 [response to stilbenoid]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043691 [reverse cholesterol transport]
GO:0044240 [multicellular organismal lipid catabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0055088 [lipid homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0065005 [protein-lipid complex assembly]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0072562 [blood microparticle]
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 396 aa
45.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.