Cell atlas - CEP164 - The Human Protein Atlas

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CEP164

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CEP164
Gene description	Centrosomal protein 164kDa
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the centrosome. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (supported)
Additional location	In addition localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA037606
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the centrosome. In addition localized to the nucleoplasm.

Main location

Centrosome (supported)

Additional location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037606	A-431	Nucleoplasm
	HPA037606	A-431	Centrosome
	HPA037606	U-2 OS	Centrosome
	HPA037606	U-251 MG	Nuclear speckles
	HPA037606	U-251 MG	Centrosome

GENE INFORMATION
Gene name	CEP164 (HGNC Symbol)
Synonyms	KIAA1052, NPHP15
Description	Centrosomal protein 164kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	117314557 - 117413268
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110274 (version 83.38)
Entrez gene	22897
UniProt	Q9UPV0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPV0
Antibodypedia	CEP164 antibodies

PROTEIN BROWSER

CEP164-001	CEP164-002	CEP164-004	CEP164-010	CEP164-011	CEP164-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP164-001 ENSP00000278935 ENST00000278935	Q9UPV0 [Direct mapping] Centrosomal protein of 164 kDa Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0005929 [cilium] GO:0006281 [DNA repair] GO:0006996 [organelle organization] GO:0007067 [mitotic nuclear division] GO:0042384 [cilium assembly] GO:0051301 [cell division] GO:0097539 [ciliary transition fiber] Show all	1460 aa 164.3 kDa	No	0
CEP164-002 ENSP00000436351 ENST00000527609	E9PLS8 [Direct mapping] Centrosomal protein of 164 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	121 aa 14.1 kDa	No	0
CEP164-004 ENSP00000431302 ENST00000533570	E9PLS8 [Direct mapping] Centrosomal protein of 164 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	121 aa 14.1 kDa	No	0
CEP164-010 ENSP00000436034 ENST00000533153	E9PR73 [Direct mapping] Centrosomal protein of 164 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	158 aa 17.2 kDa	No	0
CEP164-011 ENSP00000435759 ENST00000525416	E9PIM2 [Direct mapping] Centrosomal protein of 164 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	122 aa 13.4 kDa	No	0
CEP164-012 ENSP00000436609 ENST00000525734	E9PI05 [Direct mapping] Centrosomal protein of 164 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	115 aa 13.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.