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DDX6

GENERAL INFORMATION

Gene name

 DDX6

Gene description

 DEAD (Asp-Glu-Ala-Asp) box helicase 6

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA024201 , HPA026644 , CAB004668
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DDX6 (HGNC Symbol)

Synonyms

 HLR2, RCK

Description

 DEAD (Asp-Glu-Ala-Asp) box helicase 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 118747766 - 118791149

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110367 (version 83.38)

Entrez gene

 1656

UniProt

 P26196 (UniProt - Evidence at protein level)

neXtProt

 NX_P26196

Antibodypedia

 DDX6 antibodies

PROTEIN BROWSER
DDX6-001
DDX6-002
DDX6-201
DDX6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX6-001
ENSP00000442266
ENST00000534980
P26196 [Direct mapping]
Probable ATP-dependent RNA helicase DDX6
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003724 [RNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0016442 [RISC complex]
GO:0019074 [viral RNA genome packaging]
GO:0019904 [protein domain specific binding]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
Show all
 483 aa
54.4 kDa 		No 0
DDX6-002
ENSP00000433704
ENST00000526070
P26196 [Direct mapping]
Probable ATP-dependent RNA helicase DDX6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003724 [RNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0016442 [RISC complex]
GO:0019074 [viral RNA genome packaging]
GO:0019904 [protein domain specific binding]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
Show all
 483 aa
54.4 kDa 		No 0
DDX6-201
ENSP00000483902
ENST00000617381
Q8IV96 [Direct mapping]
DDX6 protein; Probable ATP-dependent RNA helicase DDX6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006417 [regulation of translation]
GO:0010501 [RNA secondary structure unwinding]
Show all
 187 aa
20.4 kDa 		No 0
DDX6-202
ENSP00000478754
ENST00000620157
P26196 [Direct mapping]
Probable ATP-dependent RNA helicase DDX6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003724 [RNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0016442 [RISC complex]
GO:0019074 [viral RNA genome packaging]
GO:0019827 [stem cell population maintenance]
GO:0019904 [protein domain specific binding]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0045665 [negative regulation of neuron differentiation]
Show all
 483 aa
54.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.