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AMBRA1

GENERAL INFORMATION

Gene name

 AMBRA1

Gene description

 Autophagy/beclin-1 regulator 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA038535 , CAB017825
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AMBRA1 (HGNC Symbol)

Synonyms

 DCAF3, FLJ20294, KIAA1736, WDR94

Description

 Autophagy/beclin-1 regulator 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 46396414 - 46594125

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110497 (version 83.38)

Entrez gene

 55626

UniProt

 Q9C0C7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9C0C7

Antibodypedia

 AMBRA1 antibodies

PROTEIN BROWSER
AMBRA1-001
AMBRA1-002
AMBRA1-005
AMBRA1-006
AMBRA1-007
AMBRA1-008
AMBRA1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMBRA1-001
ENSP00000431926
ENST00000534300
Q9C0C7 [Direct mapping]
Activating molecule in BECN1-regulated autophagy protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006914 [autophagy]
GO:0008285 [negative regulation of cell proliferation]
GO:0016236 [macroautophagy]
GO:0021915 [neural tube development]
GO:0030154 [cell differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045335 [phagocytic vesicle]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1903599 [positive regulation of mitophagy]
GO:2000785 [regulation of autophagosome assembly]
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 1238 aa
135.5 kDa 		No 0
AMBRA1-002
ENSP00000433372
ENST00000533727
A0A075B6T1 [Direct mapping]
Activating molecule in BECN1-regulated autophagy protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006914 [autophagy]
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 1179 aa
129.6 kDa 		No 0
AMBRA1-005
ENSP00000415327
ENST00000458649
Q9C0C7 [Direct mapping]
Activating molecule in BECN1-regulated autophagy protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006914 [autophagy]
GO:0016236 [macroautophagy]
GO:0030154 [cell differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1903599 [positive regulation of mitophagy]
GO:2000785 [regulation of autophagosome assembly]
Show all
 1298 aa
142.5 kDa 		No 0
AMBRA1-006
ENSP00000318313
ENST00000314845
Q9C0C7 [Direct mapping]
Activating molecule in BECN1-regulated autophagy protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006914 [autophagy]
GO:0016236 [macroautophagy]
GO:0030154 [cell differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1903599 [positive regulation of mitophagy]
GO:2000785 [regulation of autophagosome assembly]
Show all
 1208 aa
132.8 kDa 		No 0
AMBRA1-007
ENSP00000433945
ENST00000528950
Q9C0C7 [Direct mapping]
Activating molecule in BECN1-regulated autophagy protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0006914 [autophagy]
GO:0016236 [macroautophagy]
GO:0030154 [cell differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1903599 [positive regulation of mitophagy]
GO:2000785 [regulation of autophagosome assembly]
Show all
 1269 aa
139.3 kDa 		No 0
AMBRA1-008
ENSP00000431486
ENST00000526606
E9PL55 [Direct mapping]
Activating molecule in BECN1-regulated autophagy protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006914 [autophagy]
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 24 aa
2.7 kDa 		No 0
AMBRA1-011
ENSP00000434895
ENST00000526545
H0YE34 [Direct mapping]
Activating molecule in BECN1-regulated autophagy protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006914 [autophagy]
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 256 aa
26.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.