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CHKA

CANCER ATLAS

Gene description

 Choline kinase alpha

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024153

GENE INFORMATION

Gene name

 CHKA (HGNC Symbol)

Synonyms

 CHK, CKI

Description

 Choline kinase alpha (HGNC Symbol)

Entrez gene summary

 The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 68052859 - 68121444

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110721 (version 83.38)

Entrez gene

 1119

UniProt

 P35790 (UniProt - Evidence at protein level)

neXtProt

 NX_P35790

Antibodypedia

 CHKA antibodies

PROTEIN BROWSER
CHKA-001
CHKA-002
CHKA-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHKA-001
ENSP00000265689
ENST00000265689
P35790 [Direct mapping]
Choline kinase alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004103 [choline kinase activity]
GO:0004104 [cholinesterase activity]
GO:0004305 [ethanolamine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006580 [ethanolamine metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006657 [CDP-choline pathway]
GO:0006869 [lipid transport]
GO:0007165 [signal transduction]
GO:0008144 [drug binding]
GO:0009636 [response to toxic substance]
GO:0016310 [phosphorylation]
GO:0019695 [choline metabolic process]
GO:0033265 [choline binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:1904681 [response to 3-methylcholanthrene]
Show all
 457 aa
52.2 kDa 		No 0
CHKA-002
ENSP00000348454
ENST00000356135
P35790 [Direct mapping]
Choline kinase alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004103 [choline kinase activity]
GO:0004305 [ethanolamine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006657 [CDP-choline pathway]
GO:0006869 [lipid transport]
GO:0007165 [signal transduction]
GO:0008144 [drug binding]
GO:0016310 [phosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
 439 aa
50.2 kDa 		No 0
CHKA-006
ENSP00000435032
ENST00000531341
E9PM06 [Direct mapping]
Choline kinase alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 156 aa
17.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.